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Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
BackgroundP2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [ 11 C]SMW139...
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PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139
BackgroundNon-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide...
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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
PurposeThe novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The...
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Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation
The P2X 7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X 7 receptor is also an interesting target...
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Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties
Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society....
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Agonists, Antagonists, and Modulators of P2X7 Receptors
The P2X7 receptor has been proposed as a novel drug target for different types of diseases associated with inflammation, including brain diseases,...
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PET Imaging of Purinergic Receptors
Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic...
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PET Imaging to Measure Neuroinflammation In Vivo
This paper provides an overview of the role of neuroinflammation in Alzheimer’s disease and other neurodegenerative diseases, highlighting the...
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Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer’s Disease Continuum
In the past years, neuroinflammation has been widely investigated in Alzheimer’s disease (AD). Evidence from animal, in vivo and post-mortem studies...
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Improved syntheses of P2X7 ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or iodine-125
AbstractP2X 7 sites are emerging targets for molecular imaging research, notably in the context of neurodegeneration and inflammatory conditions....
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Microglial Activation and Neuroinflammation
Several neurological and psychiatric disorders have been associated with neuroinflammation, defined by the activation of microglia and astrocytes in...
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
Cardiovascular diseases (CVDs) are a matter of concern worldwide, and mitochondrial dysfunction is one of the major contributing factors. Vascular...
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PET Biomarkers in Psychiatry
Positron-emission tomography (PET) is an important tool that allows us to see in vivo biochemical processes in the brain. PET imaging studies in...
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis
Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the central nervous system (CNS), characterized by the loss of...
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Comprehensive review on design perspective of PET ligands based on β-amyloids, tau and neuroinflammation for diagnostic intervention of Alzheimer’s disease
PurposeAlzheimer’s disease (AD) is a progressive neurodegenerative pathological condition that resulted from the deterioration of cholinergic neurons...
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Molecular Imaging in Neurology
Radioisotope-based molecular imaging (MI) techniques such as PET/CT and SPECT/CT aim to integrate patient-specific and disease-specific molecular...
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Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
PurposeA limit on develo** new treatments for a number of central nervous system (CNS) disorders has been the inadequate understanding of the in...
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PET and PET/MRI Methods
The goal of this chapter is to provide the reader with a basic understanding of Positron Emission Tomography (PET) imaging and simultaneous PET and...