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Ex vivo cultivated retinal pigment epithelial cell transplantation for the treatment of rabbit corneal endothelial dysfunction
ObjectiveStem cell therapy is a promising strategy for the treatment of corneal endothelial dysfunction, and the need to find functional alternative...
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An In Vitro Bilayer Model of Human Primary Retinal Pigment Epithelial and Choroid Endothelial Cells for Permeability Studies
The blood-retinal barrier (BRB) present in the posterior chamber of the eye plays a major role in maintaining the proper function and integrity of... -
Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis
BackgroundThe aim of this study was to report the clinical profile and outcomes of retinal pigment epithelial detachment (PED) in...
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Increased sodium fluorescein transport by corticosteroids is inhibited by a LAT-1 specific inhibitor in retinal pigment epithelial cells in vitro
To investigate whether aldosterone (ALD) and hydrocortisone (HC) change the gene expression of SLC7A5, which encodes the large neutral amino acid...
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Predicting retinal pigment epithelium remodelling and its functional impact
PurposeTo identify predictive factors for RPE tear remodelling and its correlation with functional and morphological outcomes.
Methods ... -
Automated evaluation of retinal pigment epithelium disease area in eyes with age-related macular degeneration
The retinal pigment epithelium (RPE) is essential for the survival and function of retinal photoreceptor cells. RPE dysfunction causes various...
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Epidemiology of Mutations in the 65-kDa Retinal Pigment Epithelium (RPE65) Gene-Mediated Inherited Retinal Dystrophies: A Systematic Literature Review
IntroductionInherited retinal dystrophies (IRDs) represent a genetically diverse group of progressive, visually debilitating diseases. Adult and...
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TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Increasing evidence suggests that chronic inflammation plays an important role in the pathogenesis of age-related macular degeneration (AMD);...
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Acute Retinal Pigment Epitheliitis
Acute retinal pigment epitheliitis is a rare, idiopathic, self-limited inflammatory condition of the outer retina and retinal pigment epithelium of... -
Boundary-Repairing Dual-Path Network for Retinal Layer Segmentation in OCT Image with Pigment Epithelial Detachment
Automatic retinal layer segmentation in optical coherence tomography (OCT) images is crucial for the diagnosis of ocular diseases. Currently,...
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Small Noncoding RNA in Regulation of Differentiation of Retinal Pigment Epithelium
AbstractDedifferentiation and epithelial-mesenchymal transition (EMT) of human retinal pigment epithelial (RPE) cells, as well as the participation...
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A novel miR-338-3p/SLC1A5 axis reprograms retinal pigment epithelium to increases its resistance to high glucose-induced cell ferroptosis
BackgroundOxidative stress-induced cell ferroptosis occurs during the pathogenesis of diabetic retinopathy (DR), but the detailed molecular...
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Characteristics of retinal pigment clumps in Type 2 macular telangiectasia (MacTel)
ObjectiveTo assess the relationship of retinal pigment clump (RPC) size and its location with visual acuity and retinal neovascularisation in eyes...
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Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic and non-diabetic retinopathy: associated factors and anatomical correlation
BackgroundThis study aims to investigate the factors affecting the vitreous levels of pigment epithelium-derived factor (PEDF) and vascular...
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Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among...
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Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly. Progressive dystrophy of the retinal pigment epithelium...
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Retinal Detachment
Detachment of the retina signifies an inward separation of the sensory part of the retina from the retinal pigment epithelium (RPE). There is an... -
Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex
BackgroundThe retinal pigment epithelium (RPE), a layer of pigmented cells that lies between the neurosensory retina and the underlying choroid,...