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The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to...
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Physiological and Pharmacological Characteristics of Native Proton-Activated Ion Channels
Proton-activated ion channels (ASICs) are widely distributed in the CNS and take part in many physiological processes. We report here studies...
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Strengthening the basics: acids and bases influence vascular structure and function, tissue perfusion, blood pressure, and human cardiovascular disease
Acids and their conjugate bases accumulate in or dissipate from the interstitial space when tissue perfusion does not match the metabolic demand....
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Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase–Independent Acid Sensing of Mouse Olfactory Sensory Neurons
Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main...
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Bicarbonate secretion and acid/base sensing by the intestine
The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular as well as the luminal pH and is an essential part of...
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Brain Mechanisms Underlying Panic Attack and Panic Disorder
Panic disorder is a psychiatric disorder characterized by recurrent panic attacks, with a prevalence of ~ 4% in the general population, causing heavy...
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Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect
Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na + channels that are activated by extracellular acidification. ASICs play...
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Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus
Acid-sensing ion channels (ASICs) are voltage-independent and proton-gated channels. In this study, we aimed to test the hypothesis whether ASICs...
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Pathophysiological Mechanisms of Visceral Pain
For this chapter, based on the previous introduction of visceral pain from the anatomy and physiology perspectives, further exploration of the...
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A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights into channel structure and...
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Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells
Mammalian expression systems, particularly the human embryonic kidney (HEK-293) cells, combined with electrophysiological studies, have greatly...
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Potentiation and Block of ASIC1a by Memantine
Acid-sensing ion channels (ASICs) are modulated by various classes of ligands, including the recently described hydrophobic monoamines, which inhibit...
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Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton...
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Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation
Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the...
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The Role of the C-terminal Intracellular Domain in Acid-Sensing Ion Channel 3 Functioning
AbstractAn increase in the concentration of protons in the synaptic cleft during neurotransmitters release is considered as one of the possible ways...
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Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling
Protein domains are the basic units of protein structure and function. Comparative analysis of genomes and proteomes showed that domain recombination...
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The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis
Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis...
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New Oral Drugs for Migraine
Migraine is a common and disabling neurological disorder, with several manifestations, of which pain is just one. Despite its worldwide prevalence,...
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Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
Acetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its...
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Protein Delivery and Mimicry
The multiple examples of the strategiesConjugation of the use of CPPs to shuttle the proteinsComplexation and protein mimicsProtein mimic and their...