Pathophysiological Mechanisms of Visceral Pain

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Visceral Pain
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Abstract

For this chapter, based on the previous introduction of visceral pain from the anatomy and physiology perspectives, further exploration of the etiology and the receptor and regulation of visceral pain will be done to enable the perception of visceral pain from a pathophysiological perspective.

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References

  1. Sikandar S, Dickenson AH. Visceral pain. Curr Opin Support Palliat Care. 2012;6(1):17–26.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Zhang B, Li X, Ma Z, Zhang S, Song X, Gao H, et al. Prevalence and management of pain in lung cancer patients in northern China: a multicenter cross-sectional study. Thorac Cancer. 2022;13(11):1684–90.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pulmonary embolism [Internet]. Pulmonary embolism. Johns Hopkins Medicine. 2021 [cited 2023 Apr 3]. https://www.hopkinsmedicine.org/health/conditions-and-diseases/pulmonary-embolism.

  4. Thompson AD, Shea MJ. Chest pain—cardiovascular disorders [Internet]. MSD manual professional ed. MSD Manuals. 2023 [cited 2023 Apr 3]. https://www.msdmanuals.com/professional/cardiovascular-disorders/symptoms-of-cardiovascular-disorders/chest-pain

  5. Dye JR, Kaul MS, St. Clair EW. Inflammatory diseases of the coronary arteries. In: Lanzer P, editor. PanVascular medicine. Berlin: Springer; 2014. https://doi.org/10.1007/978-3-642-37393-0_64-1.

    Chapter  Google Scholar 

  6. White James C. Cardiac pain. Circulation. 1957;16(4):644–55.

    Article  Google Scholar 

  7. Thoracic spinal nerves [Internet]. Physiopedia. [cited 2023 Apr 3]. https://www.physio-pedia.com/Thoracic_Spinal_Nerves.

  8. Lv Y, Tian W, Chen D, Liu Y, Wang L, Duan F. The prevalence and associated factors of symptomatic cervical spondylosis in Chinese adults: a community-based cross-sectional study. BMC Musculoskelet Disord. 2018;19(1):325.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Cervellin G, Mora R, Ticinesi A, Meschi T, Comelli I, Catena F, et al. Epidemiology and outcomes of acute abdominal pain in a large urban emergency department: retrospective analysis of 5,340 cases. Ann Transl Med. 2016;4(19):362.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Peptic ulcer [Internet]. Mayo Clinic. Mayo Foundation for Medical Education and Research. 2022 [cited 2023 Apr 3]. https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223.

  11. Christian-Miller N, Frenette C. Hepatocellular cancer pain: impact and management challenges. J Hepatocell Carcinoma. 2018;5:75–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Al-Dasuqi K, Irshaid L, Mathur M. Radiologic-pathologic correlation of primary retroperitoneal neoplasms. Radiographics. 2020;40(6):1631–57.

    Article  PubMed  Google Scholar 

  13. Manyozo S. Low back pain during pregnancy: prevalence, risk factors and association with daily activities among pregnant women in Urban Blantyre, Malawi. Malawi Med J. 2019;31(1):71.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Backhausen MG, Bendix JM, Damm P, Tabor A, Hegaard HK. Low back pain intensity among childbearing women and associated predictors. A cohort study. Women Birth. 2019;32(4):e467.

    Article  PubMed  Google Scholar 

  15. Sacerdote P, Levrini L. Peripheral mechanisms of dental pain: the role of Substance P. Mediat Inflamm. 2012;2012:1–6.

    Article  Google Scholar 

  16. Waxenbaum JA, Reddy V, Varacallo M. Anatomy, autonomic nervous system. Treasure Island, FL: StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK539845/.

    Google Scholar 

  17. Pain principles (section 2, Chapter 6) neuroscience online: an electronic textbook for the Neurosciences. Department of Neurobiology and Anatomy—the University of Texas Medical School at Houston [Internet]. [Cited 2023 Apr 3]. https://nba.uth.tmc.edu/neuroscience/m/s2/chapter06.html.

  18. Wang J, Ou S-W, Wang Y-J. Distribution and function of voltage-gated sodium channels in the nervous system. Channels. 2017;11(6):534–54.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Renganathan M, Cummins TR, Waxman SG. Contribution of nav1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol. 2001;86(2):629–40.

    Article  CAS  PubMed  Google Scholar 

  20. Yam M, Loh Y, Tan C, Khadijah Adam S, Abdul Manan N, Basir R. General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int J Mol Sci. 2018;19(8):2164.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Südhof TC. The cell biology of synapse formation. J Cell Biol. 2021;220(7):e202103052.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Westlund KN. Visceral nociception. Curr Rev Pain. 2000;4(6):478–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Chen S, Wang S, Rong P, Wang J, Qiao L, Feng X, et al. Acupuncture for visceral pain: neural substrates and potential mechanisms. Evid Based Complement Alternat Med. 2014;2014:1–12.

    Google Scholar 

  24. Bardoni R, Takazawa T, Tong C-K, Choudhury P, Scherrer G, MacDermott AB. Pre- and postsynaptic inhibitory control in the spinal cord dorsal horn. Ann N Y Acad Sci. 2013;1279(1):90–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Zeilhofer HU, Wildner H, Yévenes GE. Fast synaptic inhibition in spinal sensory processing and Pain Control. Physiol Rev. 2012;92(1):193–235.

    Article  CAS  PubMed  Google Scholar 

  26. Vera-Portocarrero LP, Zhang E-T, Ossipov MH, **e JY, King T, Lai J, et al. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience. 2006;140(4):1311–20.

    Article  CAS  PubMed  Google Scholar 

  27. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895–926.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Kweon H-J, Suh B-C. Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation. BMB Rep. 2013;46(6):295–304.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Dulai JS, Smith ES, Rahman T. Acid-sensing ion channel 3: an analgesic target. Channels. 2021;15(1):94–127.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BFX, Scheuer T, et al. Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a Cam motif. Cell. 1995;83(3):433–42.

    Article  CAS  PubMed  Google Scholar 

  31. Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci. 2015;72(19):3677–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Pathan H, Williams J. Basic opioid pharmacology: an update. Br J Pain. 2012;6(1):11–6.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Mayer DJ, Mao J, Holt J, Price DD. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci U S A. 1999;96(14):7731–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Johansson J, Hirvonen J, Lovró Z, Ekblad L, Kaasinen V, Rajasilta O, et al. Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects. Neuropsychopharmacology. 2019;44(9):1667–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Du X, Gamper N. Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol. 2013;11(6):621–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Jiang, H. (2024). Pathophysiological Mechanisms of Visceral Pain. In: **a, M., Fan, B., Jiang, H. (eds) Visceral Pain. Springer, Singapore. https://doi.org/10.1007/978-981-99-9167-9_4

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  • DOI: https://doi.org/10.1007/978-981-99-9167-9_4

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-9166-2

  • Online ISBN: 978-981-99-9167-9

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