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Integrated Analysis of miRNA and mRNA Regulation Network in Hypertension
Hypertension is the most common chronic disease. Early diagnosis is helpful for early medical intervention. The miRNAs and the messenger RNAs (mRNAs)...
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Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma
Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that proliferate in the bone marrow. miRNAs are promising...
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An Efficient CRISPR-Cas9 Method to Knock Out MiRNA Expression in Xenopus Tropicalis
In recent years CRISPR-Cas9 knockouts (KO) have become increasingly utilized to study gene function. MicroRNAs (miRNAs) are short noncoding RNAs,...
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Laryngeal cancer diagnosis via miRNA-based decision tree model
PurposeLaryngeal cancer (LC) is the most common head and neck cancer, which often goes undiagnosed due to the inaccessible nature of current...
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Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
BackgroundIt is well described that circulating progesterone (P4) plays a key role in several reproductive events such as oocyte maturation. However,...
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MiRNA-202 Role in Reproductive System and Gynecological Cancers
IntroductionMicroRNAs, also known as miRNAs, are small regulatory RNAs, and they also include many different types in terms of size and commission...
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Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors
AbstractLung cancer is one of the cancer types with the highest mortality worldwide. The most frequently mutated genes known to be clinically...
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Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain
Chemotherapy-induced neuropathic pain (CINP) is a dose-limiting adverse event affecting 40% of chemotherapy patients. MiRNA-mRNA interaction plays an...
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option
Sickle cell disease (SCD) is one of the most common inherited hemoglobinopathy disorders that affects millions of people worldwide. Reactivation of...
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Association between miRNA-145 and miRNA-155 expression in peripheral blood mononuclear cells of patients with multiple sclerosis: a case-control study
IntroductionMicroRNAs (miR or miRNA) are short regulatory RNAs, which modulate post-transcriptional gene expression. Dysregulation of these molecules...
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Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering
Posttranscriptional silencing by microRNAs (miRNAs) is a critical constituent of eukaryotic gene regulation. miRNAs are short (~22 nt) noncoding RNAs...
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Regulation of adipogenesis by exosomal milk miRNA
Milk is a rich source of miRNA packaged in exosomes. Evidence for the systemic uptake and tissue distribution of milk exosomes was reported in...
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Gene Reporter Assays to Study miRNA Function
This chapter describes one of the most reliable quantitative assays to test the silencing of a possible target gene by a specific miRNA using a...
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Comprehensive analysis of miRNA profiling in Schistosoma mekongi across life cycle stages
Schistosoma mekongi , a significant schistosome parasite, has various life stages, including egg, cercaria, female, and male, that play crucial roles...
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Intra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats
Our objective in this study is to determine whether intra-articular injection of miRNA-1 can attenuate the progression of OA in rats by down...
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mRNA–miRNA bipartite networks reconstruction in different tissues of bladder cancer based on gene co-expression network analysis
Bladder cancer (BC) is one of the most important cancers worldwide, and if it is diagnosed early, its progression in humans can be prevented and...
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A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
Worldwide, many lives have been lost in the recent outbreak of coronavirus disease. The pathogen responsible for this disease takes advantage of the...
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Identification of miRNA expression profile in middle ear cholesteatoma using small RNA-sequencing
BackgroundThe present study aims to identify the differential miRNA expression profile in middle ear cholesteatoma and explore their potential roles...
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Role of miRNA in Medicinal Plants Under Stress Condition
Several plant genes are activated under different stresses like drought, salt, cold, heat, light, and oxidative stress. Recently, it has been...