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1. Hepatic Injury from Chemotherapy

   Hepatotoxicity is an expanding field in hepatology and implies chemical-driven liver damage. This includes toxicity notably related to conventional...

   Laura Rubbia-Brandt in Colorectal Liver Metastasis

   Chapter 2022
   

2. Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and review of the literature

   Background

   Mifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a...

   Taylor A. Ault, David R. Braxton, ... Tse-Ling Fong in Journal of Medical Case Reports

   Article Open access 03 February 2023
   

3. Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways

   The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective...

   Jianjia Huang, Yuman Bai, ... Rongsheng Su in Journal of Zhejiang University-SCIENCE B

   Article 17 February 2023

4. Role of Berberis SSP and Acetaminophen-Induced Acute Liver Injury

   Medicinal plants are an influential source of antioxidants and the hepatoprotective effects of some of them are well established. The antioxidant...

   Sepideh Kouchaki, Fereshteh Jeivad, ... Omid Sabzevari in Pharmaceutical Chemistry Journal

   Article 01 October 2023
   

5. Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis

   Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-induced cholestasis (DIC),...

   R. E. H. Karsten, N. J. W. Krijnen, ... P. Olinga in Archives of Toxicology

   Article Open access 16 June 2022
   

6. Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report

   We report a rare case of acute liver injury by daily exposure to small amounts of chloroform in non-alcoholic fatty liver disease (NAFLD) patient....

   Yosuke Suehiro, Takuro Uchida, ... Shiro Oka in Clinical Journal of Gastroenterology

   Article 30 January 2023
   

7. Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

   Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1; also known as TAZ) are the main effectors of the...

   Ari Kwon, Na Young Lee, ... Ja Hyun Koo in Cell Death & Disease

   Article Open access 15 January 2024
   

8. Liver

   Clinically relevant macroscopic and microscopic anatomy of the liver and nutrient metabolism in the liver have been discussed. This chapter includes...

   A. C. Anand in Gastroenterology and Hepatology

   Chapter 2024
   

9. Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R^−/−mice

   Background

   Hyperlipidemia, a heterogeneous group of disorders characterized by elevated plasma lipids in the blood, causes severe health problems,...

   Fei Wang, Wei Yao, ... **aoqing Zhang in BMC Gastroenterology

   Article Open access 11 August 2023
   

10. Hepatoprotective effects of baicalein against liver ischemia-reperfusion injury and partial hepatectomy in a rat model

    Background

    Baicalein is the main active flavonoid in Scutellariae Radix and is included in shosaikoto, a Kampo formula used for treating hepatitis and...

    Tetsuya Okuyama, Richi Nakatake, ... Mitsugu Sekimoto in Molecular Biology Reports

    Article 10 May 2024
    

11. Physiological Role of Liver and Interpreting Liver Function Tests

    The purpose of this chapter is to review the anatomy and physiology of the liver as well as provide a brief interpretation of liver function tests....

    Kamal Kajal, Venkata Ganesh, Sameer Sethi in Peri-operative Anesthetic Management in Liver Transplantation

    Chapter 2023
    

12. Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen

    Acetaminophen (APAP), which is widely used for the treatment of analgesic-antipyretic as the first-line drug, can cause extensive hepatic injury and...

    Chuchu Han, Linyang Zhang, ... Ying Liu in Medicinal Chemistry Research

    Article 01 November 2022
    

13. Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase

    Alcoholic liver injury resulting from excessive alcohol consumption is a significant social concern. Alcohol dehydrogenase (ADH) plays a critical...

    Bhavya Banjan, Rajesh Raju, ... Chandran S. Abhinand in Molecular Diversity

    Article 14 May 2024
    

14. Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach

    Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e.,...

    Andres Gonzalez-Jimenez, Ayako Suzuki, ... M. Isabel Lucena in Archives of Toxicology

    Article 05 March 2021
    

15. Drug-Induced Cholangiopathies

    Since it plays a central role in the metabolism of xenobiotics, including drugs, the liver is one of the main targets of drug toxicity, often due to...

    Sara De Martin, Emanuela Bonaiuto, Daniela Gabbia in Diseases of the Liver and Biliary Tree

    Chapter 2021
    

16. Recent Advances in Regenerative Medicine of the Liver and Bile Duct System by Chemically Induced Liver Progenitor Cells (CLiPs) in Nagasaki Experience

    Liver transplantation is the only treatment for end-stage liver failure. Although the development of hepatocyte therapy is expected, hepatocyte...

    Masaaki Hidaka, Daisuke Miyamoto, Susumu Eguchi in Handbook of Stem Cell Applications

    Reference work entry 2024
    

17. Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK/NF-κB Signaling Pathway

    Albiflorin (Alb) is a monoterpenoid component that is commonly found in Paeonia lactiflora Pall . or Paeonia veitchii Lynch . It is known for its...

    Haitao Li, **angpeng Zeng, ... Yan Lin in Biochemical Genetics

    Article 21 February 2024
    

18. Liver-specific delivery of spherical DNA frameworks for alleviation of hepatic ischemic reperfusion injury

    DNA nanostructures have long been developed for biomedical purposes, but their controlled delivery in vivo proposes a major challenge for disease...

    Hao Wang, Li Wen, ... Dawei Jiang in Journal of Nanobiotechnology

    Article Open access 04 July 2024
    

19. SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease

    Background

    SARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure,...

    Ali Choaib, Elio Issa, ... Wissam H. Faour in Inflammation Research

    Article 20 December 2022
    

20. Endoplasmic reticulum stress-mediated cell death in liver injury

    The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic...

    Jian Zhang, Jiafu Guo, ... Chaolong Rao in Cell Death & Disease

    Article Open access 19 December 2022