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Synthesis and Inhibitory Activity of Atorvastatin Conjugate with a Branched Asialoglycoprotein Receptor Ligand Containing Three N-Acetyl-d-galactosamine Residues
AbstractA novel atorvastatin conjugate was synthesized by a multistep procedure, using a branched N -acetylgalactosamine ligand for...
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Marine-derived polygalactofucan and its β-2-deoxy-amino-substituted glucopyranan composite attenuate 3-hydroxy-3-methylglutaryl-CoA reductase: prospective natural anti-dyslipidemic leads
Adverse side effects reported for the use of statin drugs provided insights to develop potential anti-dyslipidemic derivatives from natural origin....
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Agrobacterial Transformation of Tobacco with a Genetic Module of the Biosynthesis of the Antimalarial Agent Artemisinin
AbstractArtemisinin-based medicines are the most effective treatment for malaria. To date, wormwood plants ( Artemisia annua L.) are the main source...
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The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi
Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma...
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Targeting metabolic reprogramming in chronic lymphocytic leukemia
Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of cancer, is considered as a promising therapeutic target against...
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With Current Safety and Efficacy Data, Should Statins Be Made Available as Nonprescription Over-the-Counter Drugs?
Purpose of ReviewStatins inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the liver and reduce atherosclerotic cardiovascular...
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Pitavastatin stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion
BackgroundExcessive angiogenesis of the retina is a key component of irreversible causes of blindness in many ocular diseases. Pitavastatin is a...
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Statin-induced autoimmune myositis: a proposal of an “experience-based” diagnostic algorithm from the analysis of 69 patients
Statin-induced autoimmune myositis (SIAM) represents a rare clinical entity that can be triggered by prolonged statin treatment. Its pathogenetic...
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Rhabdomyolysis or Severe Acute Hepatitis Associated with the Use of Red Yeast Rice Extracts: an Update from the Adverse Event Reporting Systems
Purpose of ReviewElevated plasma levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for atherosclerotic cardiovascular...
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HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis
BackgroundDisseminated Intravascular Coagulation (DIC) is a syndrome of dysregulated coagulation. Patients with sepsis are at increased risk for DIC....
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Coenzyme Q10 and SAMS
Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, thereby reducing production of farnesyl pyrophosphate, an intermediate in the...
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HMG-CoA Reductase Inhibitors for Traumatic Brain Injury
Traumatic brain injuries (TBIs) are associated with high morbidity and mortality due to both the original insult as well as the destructive...
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Production of Coenzyme Q10 by microbes: an update
Coenzyme Q 10 (CoQ 10 ) is the main CoQ species in human and is used extensively in food, cosmetic and medicine industries because of its antioxidant...
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Hypothyroidism increases angiotensinogen gene expression associated with vascular smooth muscle cells cholesterol metabolism dysfunction and aorta remodeling in Psammomys obesus
It has been previously shown that clinical cardiovascular manifestations can be caused by mild changes in thyroid function. However, the implication...
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Metabolite profiling and transcriptomic analyses demonstrate the effects of biocontrol agents on alkaloid accumulation in Fritillaria thunbergii
BackgroundDuring Fritillaria thunbergii planting, pests and diseases usually invade the plant, resulting in reduced yield and quality. Previous...
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Association between genetically proxied lipid-lowering drug targets, lipid traits, and amyotrophic lateral sclerosis: a mendelian randomization study
BackgroundThe use of circulating lipid traits as biomarkers to predict the risk of amyotrophic lateral sclerosis (ALS) is currently controversial,...
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Probiotic Characteristics of Lactiplantibacillus Plantarum N-1 and Its Cholesterol-Lowering Effect in Hypercholesterolemic Rats
In this study, the probiotic potential and treatment effects of Lactiplantibacillus plantarum N-1 in hypercholesterolemic rats were investigated, and...
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Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L
Parkinson’s Disease (PD) is caused by many factors and endoplasmic reticulum (ER) stress is considered as one of the responsible factors for it. ER...
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Role of Statins and Resveratrol in PCOS Management
Polycystic ovary syndrome (PCOS) is characterized by the presence of hyperandrogenism, menstrual cycle irregularities, and polycystic-appearing...
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Investigating genetically mimicked effects of statins via HMGCR inhibition on immune-related diseases in men and women using Mendelian randomization
Statins have been suggested as a potential treatment for immune-related diseases. Conversely, statins might trigger auto-immune conditions. To...
