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Immunology of Aging: the Birth of Inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the...
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Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability
Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic...
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Immunseneszenz und Inflammaging
Die Anti-Aging-Medizin beschäftigt sich mit allgemeinen biologischen Alterungsfaktoren. Sie untersucht aber auch das spezifische Altern einzelner...
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Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
The immune system is the central regulator of tissue homeostasis, ensuring tissue regeneration and protection against both pathogens and the...
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Probing the Interface of HIV and Inflammaging
Purpose of ReviewSystemic inflammation increases as a consequence of aging (inflammaging) and contributes to age-related morbidities. Inflammation in...
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Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue
Frailty is a new concept in rheumatology that can help identify people more likely to have less favorable outcomes. Sarcopenia and inflammaging can...
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An update on mode of action of metformin in modulation of meta-inflammation and inflammaging
Type 2 diabetes mellitus (T2DM) is the most common chronic metabolic condition. Several genetic and environmental factors are involved in develo**...
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Ageing of the Gut Microbiome and Its Potential Contribution Towards Immunesenescence and Inflammaging
The gutGut microbiomeGut microbiome playsMicrobiome an essential role in host health, mediated via its interaction with the immune system. Advancing...
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Chronic Inflammation and Aging (Inflammaging)
Research evidence has revealed that the molecular inflammatory process plays a central role in the aging process and age-related diseases....
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Age-related cerebral small vessel disease and inflammaging
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a...
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Chemokine CXCL9, a marker of inflammaging, is associated with changes of muscle strength and mortality in older men
SummaryOur study examined associations of the CXC motif chemokine ligand 9 (CXCL9), a pro-inflammatory protein implicated in age-related...
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Nutrition and Diabetes in the Context of Inflammaging
Purpose of ReviewTo update the concepts of inflammaging and the development of insulin resistance and type 2 diabetes mellitus (T2DM); to summarize...
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Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the...
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Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly identified contributor to diabetes-related tissue lesions,...
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Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection
BackgroundThe SARS-CoV-2 pandemic continues to spread sporadically in the Unites States and worldwide. The severity and mortality excessively...
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Senescent macrophages in the human adipose tissue as a source of inflammaging
Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation. Recent evidence suggests that an increased...
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Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms
PurposeThere is considerable controversy on the role of genetics, mechanical and environmental factors, and, recently, on subclinical infection in...
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Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model
Rapamycin (RAPA) is found to have neuro-protective properties in various neuroinflammatory pathologies, including brain aging. With magnetic...
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Mitochondria, immunosenescence and inflammaging: a role for mitokines?
A global resha** of the immune responses occurs with ageing, indicated as immunosenescence, where mitochondria and mitochondrial metabolism play an...
