697 Result(s)
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Article
Open AccessRefracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study
There is imminent refracture risk in elderly individuals for up to six years, with a decline thereafter except in women below 75 who face a constant elevated risk. Elderly men with fractures face the highest m...
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Open AccessOsteoporosis and fracture risk assessment in adults with ischaemic stroke
To study the prevalence of osteoporosis, falls and fractures in adults with ischaemic stroke.
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Open AccessDelayed and significant hypercalcaemia due to teriparatide therapy: a case report and review
Transient hypercalcaemia due to teriparatide occurs in up to 11% of patients though delayed hypercalcaemia (> 24 h post injection) is rare. We report the case of a female who developed significant delayed hype...
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Open AccessRomosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials
Post hoc analysis of FRAME and ARCH revealed that on-study nonvertebral and vertebral fractures by Month 12 were less common in women initially treated with romosozumab versus placebo or alendronate. Recurrent...
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Open AccessOutdoor walking, genetic predisposition, and the risk of incident osteoporosis among older adults: A prospective large population-based cohort study
This large-scale prospective study showed that a significant association between longer duration of daily outdoor walking and reduced osteoporosis risk was found among older adults, particularly among those wi...
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Open AccessEffectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis
To determine and appraise the certainty of fracture liaison service (FLS) in reducing the risk of secondary fragility fractures in older adults aged ≥ 50 years and to examine the nature of the FLS and the role...
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Open AccessNutritional status as independent prognostic factor of outcome and mortality until five years after hip fracture: a comprehensive prospective study
We determined the prognostic value of nutritional status for outcome after hip fracture. Nutritional status was a strong independent prognostic factor for clinical outcome and 5-year mortality. Physical functi...
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Open AccessCost-effectiveness of romosozumab for the treatment of postmenopausal women with osteoporosis at high risk of fracture in Belgium
This study evaluated the cost-effectiveness of sequential treatment with romosozumab-to-alendronate compared to alendronate monotherapy and teriparatide-to-alendronate, in postmenopausal osteoporotic women fro...
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Open AccessThe effect of romosozumab on bone mineral density depending on prior treatment: a prospective, multicentre cohort study in Switzerland
This multicentre, prospective cohort study measured the effect of romosozumab for 12 months on bone mineral density, taking into account prior therapies. Prior antiresorptive therapy blunted the BMD response t...
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Article
Open AccessThe hip fracture incidence in the high-risk area Oslo continues to decline
Oslo in Norway has had the highest incidence of hip fractures in the world. The incidence in Oslo has been thoroughly described every decade since the late 1970s. The incidence in Oslo has previously been high...
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Open AccessEducational gradient in hip fracture incidence in Norway. The Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)
Examining fracture dynamics by socioeconomic status may inform healthcare and prevention. We found a higher risk of hip fracture in men and women with lower educational level in Norway. However, by age 90 + ye...
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Open AccessA novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis
In severe osteoporosis, the optimal approach for sequential treatment between denosumab and romosozumab is unclear. We utilised a novel overlap** strategy in three patients with very-high fracture risk despi...
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Article
Open AccessHip fractures in patients with primary aldosteronism – a Swedish nationwide study
In this large population-based matched cohort study, patients with primary aldosteronism were at increased risk of hip fracture, particularly subgroups traditionally considered at higher risk of osteoporosis s...
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Open AccessAssociations between ultra-distal forearm bone mineral density and incident fracture in women
Bone mineral density measured at the ultra-distal forearm site was associated with any fracture, as well as distal radius fracture in women from a longitudinal cohort study.
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Open AccessThe significance of recent fracture location for imminent risk of hip and vertebral fractures—a nationwide cohort study on older adults in Sweden
The role of recent fracture site in predicting the most detrimental subsequent fractures, hip and vertebral, is unclear. This study found that most recent fracture sites were associated with an increased risk ...
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Article
Open AccessMetformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study
It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment ...
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Article
Open AccessCT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis
The use of opportunistic computed tomography (CT) image-based biomarkers may be a low-cost strategy for screening older individuals at high risk for osteoporotic fractures and populations that are not sufficie...
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Open AccessPhysical function trajectory after wrist or lower arm fracture in postmenopausal women: results from the Women’s Health Initiative Study
Long-term physical functioning trajectories following distal forearm fracture are unknown. We found that women with versus those without distal forearm fracture were more likely to experience a 5-year decline ...
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Article
Open AccessAssociation between socioeconomic deprivation and bone health status in the UK biobank cohort participants
The effect of deprivation on total bone health status has not been well defined. We examined the relationship between socioeconomic deprivation and poor bone health and falls and we found a significant associa...
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Open AccessShould major trauma fractures be part of a fracture liaison service’s remit: a cost–benefit estimate
The refracture rate after major trauma is approximately half (57%) the refracture rate after a minimal trauma injury.
