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Modeling Calcium Waves
We present an introduction to the mathematics of calcium waves, both intracellular and intercellular. After a discussion of the earlier models I...
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Regulation of IP 3 Receptors by IP 3 and Ca 2+
Inositol 1,4,5-trisphosphate ( IP 3) receptors are intracellular Ca 2+ channels that mediate release of Ca 2+ from intracellular stores. The channels...
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Hormone-Mediated Intercellular Calcium Signalling in an Insect Salivary Gland – Pathways and Mechanisms
The salivary glands of the blowfly Calliphora vicina are a favourable preparation for investigations into spatio-temporal Ca 2+ dynamics in an intact...
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From Simple to Complex Ca 2+ Oscillations: Regulatory Mechanisms and Theoretical Models
Intracellular Ca 2+ oscillations most often appear as regular spikes. However, complex Ca 2+ oscillations in the form of bursting or chaos have also...
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The Endoplasmic Reticulum: A Central Player in Cell Signalling and Protein Synthesis
In addition to being the principle intracellular Ca 2+ store, the endoplasmic reticulum (ER) is the initial site of synthesis and folding of membrane...
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Global and Local Regulation of Neuronal Differentiation by Calcium Transients
Embryonic spinal neurons express ion channels prior to synaptogenesis that mediate specialized forms of excitability promoting Ca 2+ influx. Ca 2+...
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Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling
We outline the roles of two low molecular weight phosphorylated compounds as intracellular messengers in calcium signaling. These new intracellular...
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Mitochondrial and ER Calcium Uptake and Release Fluxes and their Interplay in Intact Nerve Cells
Ionized free Ca ( Ca 2+) is a ubiquitous signaling ion that serves as the critical link between a variety of physiological stimuli and their...
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Building a Wave – Models of the Puff-to-Wave Transition
Ca2+ release channels open and close randomly because of random binding and dissociation of Ca2+ and IP3 to their subunits. They are arranged in...
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Mathematical Modelling and High Resolution Fluorescence Imaging for Studying Calcium Regulation
The aim of this chapter is to describe and discuss a fundamental concept for studying cellular signalling. It is the combination of state of the art...
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Langevin Modeling of Intracellular Calcium Dynamics
Recent progress in fluorescent imaging technology has revealed that Ca 2+ is released from the endoplasmic reticulum (ER) through clusters that are...
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Information Processing in Calcium Signal Transduction
Calcium signalling often employs calcium oscillations. It is by now a well-known fact that information, e.g. about the amount of stimulus that evoked...
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Models of Cardiac Ca 2+-Induced Ca 2+ Release and Ca 2+ Sparks
This chapter will review computer models of calcium ( Ca 2+) signaling in cardiac myocytes; specifically, we will discuss mathematical treatments of...
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Solid-state NMR assignment of α-synuclein polymorph prepared from helical intermediate
Synucleinopathies are neurodegenerative diseases characterized by the accumulation of α-synuclein protein aggregates in the neurons and glial cells....
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Wave propagation in a light-temperature neural network under adaptive local energy balance
External electric and mechanical stimuli can induce shape deformation in excitable media because of its intrinsic flexible property. When the signals...
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Solid-state NMR backbone chemical shift assignments of α-synuclein amyloid fibrils at fast MAS regime
The α-synuclein (α-syn) amyloid fibrils are involved in various neurogenerative diseases. Solid-state NMR (ssNMR) has been showed as a powerful tool...
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Assessment of bone tissue cytoarchitectonics by 2D 1H NMR relaxometry maps
Bone is a complex tissue that fulfills the role of a resistance structure. This quality is most commonly assessed by bone densitometry, but bone...
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Backbone and methyl side-chain resonance assignments of the Fab fragment of adalimumab
Adalimumab is a therapeutic monoclonal antibody developed to target human TNF an important mediator of immune-mediated inflammatory diseases such as...
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Quantitative analysis of the slow exchange process by 19F NMR in the presence of scalar and dipolar couplings: applications to the ribose 2′-19F probe in nucleic acids
Solution NMR spectroscopy is a particularly powerful technique for characterizing the functional dynamics of biomolecules, which is typically...
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Assignment of the Lassa virus transmembrane domain in the prefusion and postfusion states in detergent micelles
Lassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although...
