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Formulating GML-1 Tablets Using the Harrington Desirability Function
Features of using the generalized Harrington desirability function for the selection of a binder and lubricant for GML-1 ( N -benzyl- N -methyl-1-phenylpyrrolo[1,2-...
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Quality by Design (QbD) Process Design
Quality by design (QbD) principles have become widely adopted in the pharmaceutical industry to ensure consistent quality of products through their...
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Post-Alcohol Corn Dregs as a Pharmaceutical Source for Obtaining Nitrogen-Containing Betaines
A method was developed for producing betaine hydrochlorides (with added pepsin) in the form of substances and tablets intended for use as drugs with...
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Influence of Various Disintegrants on the Quality of Microcrystalline Cellulose Tablets
The effects of the superdisintegrants sodium starch glycolate, croscarmellose sodium, polacrilin potassium Kyron T-314, and Amberlite IRP 88 on the...
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Phytochemistry and Pharmaceutical Technology Studies on Monteverdia ilicifolia (Maytenus ilicifolia): a Traditionally Used Medicinal Plant
Monteverdia ilicifolia (Mart. ex Reissek) Biral, Celastraceae (Syn. Maytenus ilicifolia Mart. ex Reissek), is used in Brazil as a folk medicine to...
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Use of Two-Factor Dispersion Analysis for Studying the Pharmaceutical and Technological Properties of Tablets of GK-2 – bis-(N-Monosuccinyl-L-Glutamyl-L-Lysine) Hexamethyleneamide, Dispersed in the Oral Cavity
The influence of the type and ratio of co-process fillers and lubricating excipients on the properties of the final dosage form was studied during...
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New Formulation Technique for Solubility and Dissolution Rate Enhancement of Poorly Soluble Drugs
Ebastine (EBS) is a second-generation non-sedating antihistamine used for the prevention and treatment of allergic rhinitis and chronic idiopathic...
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Development and Study of Anxiolytic Effect of Gml-1 Tablet Dosage Form
Novel pyrrolo[1,2- a ]pyrazine ligands of 18-kDa translocator protein (TSPO) were synthesized at Zakusov Research Institute of Pharmacology....
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Physicochemical and Technological Characteristics of Lycopus Europaeus L. Dry Herbal Extract and Related Compositions
The physicochemical and technological properties of Lycopus europaeus dry herbal extract were studied. Excipients were also selected. The...
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Oral Solids
This chapter provides the pharmaceutical basis of common solid dosage forms and discusses biopharmaceutical aspects related to their formulation....
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Compatibility of Medicinal and Excipient Substances in the Development of Medicinal Formulations
Attention is drawn to a contradiction associated with assessments of the compatibility of medicinal (MS) and excipient (ES) substances: that ES and...
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Current Trends in the Development of Technologies for Matrix Formulations with Modified Release (Review)
Current aspects of the technology used to create matrix formulations ar presented. The main types of matrix are described depending on their behavior...
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Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet
Orally disintegrating tablet (ODT) is a user friendly and convenient dosage form. The study aimed to investigate the effect of polymers and wheat...
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Oral Solids
This chapter provides the pharmaceutical basis of common solid dosage forms and discusses biopharmaceutical aspects related to their formulation....
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Improved dosage form of the combined alendronate and calcitriol (Maxmarvil®) on the absorption of alendronate in Korean postmenopausal women
Alendronate is one of the most potent anti-osteoporotic agents for postmenopausal osteoporosis. However, high doses of alendronate cause esophageal...
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Development and evaluation of self-microemulsifying liquid and granule formulations of Brucea javanica oil
The aim of this study was to develop and characterize a self-microemulsifying drug delivery system (SMEDDS) of Brucea javanica oil (BJO) and...
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Formulation and in vivo evaluation of ondansetron orally disintegrating tablets using different superdisintegrants
The aim of this study was to formulate cost effective taste-masked orally disintegrating tablets of ondansetron, a bitter drug using different...
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Preparation and evaluation of pectin-based colon-specific pulsatile capsule in vitro and in vivo
The purpose of this study was to develop and evaluate a colon-specific, pulsatile drug delivery system, which consists of an impermeable capsule body...
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Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet
The present study was undertaken to develop and evaluate an oro-dispersible, sustained release tablet of metoclopramide HCl. The technology was...
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Comparative study of telmisartan tablets prepared via the wet granulation method and pritor™ prepared using the spray-drying method
The wet granulation method was successfully used to manufacture amorphous telmisartan tablets (CNU) for comparison with the spray-drying method, used...