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Use of Two-Factor Dispersion Analysis for Studying the Pharmaceutical and Technological Properties of Tablets of GK-2 – bis-(N-Monosuccinyl-L-Glutamyl-L-Lysine) Hexamethyleneamide, Dispersed in the Oral Cavity

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Pharmaceutical Chemistry Journal Aims and scope

The influence of the type and ratio of co-process fillers and lubricating excipients on the properties of the final dosage form was studied during the development of the composition and technology for GK-2 [bis-(N-monosuccinyl-L-glutamyl-L-lysine hexamethyleneamide] tablets dispersed in the oral cavity. The pharmaceutical and technological properties, including the degree of flowability, bulk density under compaction, mass loss on drying, coefficient of compressibility (Carr’s index), tablet crushing strength, disintegration of tablets, and wear resistance, were evaluated to assess the nature and degree of influence of all composition factors. Analysis of variance considering the particular factors and their averages for all indicators was used to assess the degree of their influence. In addition, the determination coefficients were analyzed for each parameter, excluding parameters with low values from further studies.

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, 8 Baltiiskaya St., Moscow, 125315, Russia

    S. V. Tishkov, E. V. Blynskaya, K. V. Alekseev & V. V. Bueva

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  1. S. V. Tishkov
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  2. E. V. Blynskaya
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  3. K. V. Alekseev
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  4. V. V. Bueva
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Correspondence to S. V. Tishkov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 10, pp. 35 – 41, October, 2021.

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Tishkov, S.V., Blynskaya, E.V., Alekseev, K.V. et al. Use of Two-Factor Dispersion Analysis for Studying the Pharmaceutical and Technological Properties of Tablets of GK-2 – bis-(N-Monosuccinyl-L-Glutamyl-L-Lysine) Hexamethyleneamide, Dispersed in the Oral Cavity. Pharm Chem J 55, 1096–1102 (2022). https://doi.org/10.1007/s11094-021-02542-6

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  • DOI: https://doi.org/10.1007/s11094-021-02542-6

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