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An in vitro evaluation of the antioxidant activities of necroptosis and apoptosis inhibitors: the potential of necrostatin-1 and necrostatin-1i to have radical scavenging activities
BackgroundNecroptosis inhibitors, including necrostatin-1 (Nec-1), are attracting attention as potential therapeutic agents against various diseases,...
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Embriotoxic and Antioxidant Effects of Cymbopogon citratus Leaf Volatile Oil on Zebrafish
This study aimed to characterize the phytochemical composition and in vivo embryotoxic potential of Cymbopogon citratus Stapf, Poaceae, volatile oil...
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Nephroprotective Effects of Hesperidin and Myricetin Against High-Fat Diet Plus Ethanol-Induced Renal Oxidative Damage in Mice
Hesperidin and myricetin are natural flavonoids that exhibit antioxidant activity, but their effects against high-fat diet plus ethanol-induced renal...
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The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells
BackgroundNon-steroidal anti-inflammatory drugs have been shown to inhibit the development of induced neoplasms. Our previous research demonstrated...
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Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus
The effect of the synthetic compound 2-morpholino-5-phenyl-6 H -1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model...
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Resveratrol Attenuates Non-alcoholic Fatty Liver Disease in Obese Mice Modulating MAF1
In the present study, we aimed to evaluate the resveratrol effects on MAF1 liver pathway using a mice model of non-alcoholic fatty liver disease...
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Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer. The purpose of this research was to examine if the...
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In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside in rheumatoid arthritis....
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Liquiritin Relieves LPS-Induced Endometritis Through Activating Keap1/Nrf2/HO-1 Signaling Pathway
Liquiritin is a flavonoid extracted from Glycyrrhiza glabra L., Fabaceae, which possesses anti-inflammatory and antioxidant activities. However, the...
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Alisol B 23-Acetate Affects a Podocyte Injury Model by Inhibiting PI3K/AKT/mTOR Signaling
Diabetic nephropathy is the leading cause of impaired renal function. Podocyte injury is a crucial factor during the pathological process of diabetic...
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Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
BackgroundThe use of amphotericin B (AmB) in the therapy of systemic mycosis is associated with strong side effects, including nephrotoxicity, and...
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Protective Effect of Raspberry Ketone on Deep Vein Thrombosis and the Molecular Mechanism
Endothelial cell dysfunction is closely related to deep vein thrombosis, and oxidative damage of endothelial cells is an important cause of...
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A Novel Multi-Supplement Based on Guarana, Selenium, and L-Carnitine Reduces Organ-Specific Oxidative Stress But Not Oxidative Stress-Induced Anxiety
Acute restrain stress promotes an inflammatory microenvironment mediated by oxidative damage. There is a need to design novel supplements based on...
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Beneficial Effects of Punica granatum L. Juice and Gallic Acid Against Kidney Oxidative Damage Caused by Sodium Fluoride
The present work was undertaken to study the effect of sodium fluoride (NaF) exposure on renal oxidative stress status in rats and to evaluate the...
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Betulinic Acid Modulates Redox Imbalance and Dysregulated Metabolisms, While Ameliorating Purinergic and Cholinergic Activities in Iron-Induced Neurotoxicity
The neuroprotective properties of betulinic acid were investigated in oxidative-mediated neurotoxicity induced with Fe 2+ in isolated rats’ brains....
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Grape Seed and Skin Extract Protects Against Doxorubicin Chemotherapy-Induced Oxidative Stress, Inflammation and Metabolic Enzyme Disturbances in Rat Lung
Doxorubicin (Doxo), a widely used antitumor anthracycline antibiotic, is the angular stone in the treatment of many neoplasic diseases though also...
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The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood
BackgroundPhencyclidine, an NMDA receptor antagonist, is frequently used to model behavioral and neurochemical changes correlated with schizophrenia...
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Capillarisin Pretreatment Inhibits Oxidative Stress and Inflammation in Rats After Myocardial Infarction Induction
Myocardial infarction is a type of cardiovascular disease that leads to the loss of cardiomyocyte and cardiac dysfunction and is classified as the...
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Palmatine Alleviates Acute Myocardial Infarction Through Activating pAMPK/Nrf2 Signaling Pathway in Mouse Model
Acute myocardial infarction is one of the major leading causes for heart failure, which can lead to the irreversible loss of cardiomyocytes and...
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Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is...
