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Beneficial Effects of Punica granatum L. Juice and Gallic Acid Against Kidney Oxidative Damage Caused by Sodium Fluoride

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The present work was undertaken to study the effect of sodium fluoride (NaF) exposure on renal oxidative stress status in rats and to evaluate the protective effects of both Punica granatum L. (PGJ) juice and gallic acid (GA). Thirty-six maleWistar rats were divided into six groups: C (n = 6) served as a control; NaF (n = 6) were treated with NaF at 100 ppm; NaF+GA(n = 6) were administered NaF at 100 ppm plus 20 mg/kg of GA; NaF+PGJ (n = 6) were treated by both NaF (100 ppm) and PGJ (1 mL); NaF+GA+PGJ (n = 6) were treated with NaF at 100 ppm plus both GA(20 mg/kg) and PGJ (1 ml); and PGJ (n = 6): received 1 mL of PGJ. After three weeks, data showed that NaF administration caused a rise in urea, creatinine, uric acid, and malondialdehyde (MDA) levels and a decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities as well as reduced glutathione level. Furthermore, histological examination revealed a moderate inflammatory infiltration. However, supplementation of GA and/or PGJ improved both the renal histological structure and all other studied parameters. The obtained results clearly showed the ability of P. granatum juice and gallic acid to protect renal tissues from oxidative damage caused by sodium fluoride.

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Acknowledgments

The present research was supported by the Algerian Ministry of Higher Education and Scientific Research, Directorate General for Scientific Research and Technological Development through the Research Laboratory of Biochemical and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, Annaba, Algeria.

CONFLICT OF INTEREST STATEMENT

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Natural and Life Sciences, Mohamed Cherif Messaadia University, Souk Ahras, Algeria

    Asma Bouasla & Choukri Barour

  2. Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria

    Asma Bouasla, Ihcène Bouasla & Mahfoud Messarah

  3. Laboratory of Aquatic and Terrestrial Ecosystems, Faculty of Natural and Life Sciences, Mohamed Cherif Messaadia University, Souk Ahras, Algeria

    Choukri Barour

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  1. Asma Bouasla
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Correspondence to Asma Bouasla.

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Bouasla, A., Barour, C., Bouasla, I. et al. Beneficial Effects of Punica granatum L. Juice and Gallic Acid Against Kidney Oxidative Damage Caused by Sodium Fluoride. Pharm Chem J 55, 920–928 (2021). https://doi.org/10.1007/s11094-021-02516-8

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