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Preclinical efficacy of cannabidiol for the treatment of early-life seizures
BackgroundThe treatment of epilepsy during early life poses unique challenges—first-line therapies leave many individuals with poorly controlled...
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Molecular insights into the therapeutic promise of targeting HMGB1 in depression
Depression is a common psychiatric disorder, the exact pathogenesis of which is still elusive. Studies have proposed that immunity disproportion and...
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Defining Clinical Trial Estimands: A Practical Guide for Study Teams with Examples Based on a Psychiatric Disorder
While the ICH E9(R1) Addendum on “Estimands and Sensitivity Analysis in Clinical Trials” was released in late 2019, the widespread implementation of...
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Voltammetric Determination of Diphenhydramine Hydrochloride in Solid and Liquid Dosage Forms
A method for accelerated determination of diphenhydramine hydrochloride (dimedrol, DPH) in liquid and solid dosage forms (DFs) that is based on...
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Consider cannabinoids as an individual therapeutic trial in nociplastic pain
Nociplastic pain, which is characterized by widespread chronic pain and a range of central nervous system and other somatic symptoms, is associated...
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Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions
Thyroid hormones (THs) play an important role in the regulation of energy metabolism. They also take part in processes associated with the central...
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Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review
During the period of mass industrial production of plastic products, the quality of human health has decreased significantly, especially in...
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Preclinical models of treatment-resistant depression: challenges and perspectives
Treatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to...
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Potential drugs for the treatment of Alzheimer’s disease
It is well known that amyloid precursor protein (APP), the enzyme β-secretase 1 (BACE1), cyclooxygenase 2 (COX-2), nicastrin (NCT), and...
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Manage antipsychotic-induced akathisia by making changes to the antipsychotic drug regimen and/or adding anti-akathisia agents
Antipsychotic-induced akathisia (AIA) is a common and distressing adverse effect associated with many first- and second-generation antipsychotics....
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Deprescribing
Deprescribing refers to reducing or stop** medications that may no longer be needed, may be causing more harm than good, or may not align with a...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists
Over the last decade, new psychoactive substances (NPS) have continuously been the focus of the international society since their emergence on the...
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Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis
Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways involved in neurodegenerative disorders. Metformin, an...
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Targeting the CCL2-CCR2 axis in depressive disorders
Since affective disorders are considered to be underlain by the immune system malfunction, an important role in their pathophysiology is assigned to...
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Individualize treatment when prescribing medical cannabis to older patients as efficacy data remains limited
There is a growing interest in the use of cannabis for medical purposes, especially in older patients who experience pain, sleep difficulties, mood...
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Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials
BackgroundDue to unmet clinical needs for efficient drugs with a rapid onset of antidepressant effects, we aimed to evaluate the efficacy of...
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Synthesis and anticonvulsant screening of 1,2,4-triazole derivatives
BackgroundCurrently available antiepileptic drugs offer limited symptomatic treatment and fail to cure more than 30% of the epileptic seizures....
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Frequency and nature of potential drug–drug interaction in medical wards: a cross-sectional study in a teaching hospital
BackgroundThe safety and proper utilization of a drug depends not only on its pharmacological action, but also its interactions with other drugs and...
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A critical review of pyritinol
Pyritinol (pyrithioxine) is a combination of two molecules of vitamin B 6 (pyridoxine) with disulfide linkage. Its pharmacokinetic profile mimics that...