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Logistic Regression Model: The Effect of Endogenous Magnesium Level on the Concentration of Magnesium Drugs in a Bioequivalence Study
The comparative bioavailability and bioequivalence of drugs containing magnesium citrate were studied. Logistic regression models were constructed to...
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Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies
BackgroundMagnesium ions (Mg 2+ ) increase and prolong opioid analgesia in chronic and acute pain. The nature of this synergistic analgesic...
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Manage idiopathic hypersomnia with a combination of non-pharmacological and pharmacological treatments
Idiopathic hypersomnia (IH) is a rare slee** disorder that is difficult to diagnose, and little is known about its pathophysiology. A defining...
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Treat functional constipation in children with conventional options first and consider alternatives if needed
The treatment of functional constipation in children includes faecal disimpaction and maintenance therapy. Conventional treatment options, such as...
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Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats
BackgroundKetamine and magnesium sulphate showed synergic interaction in the tail-immersion test and additive interaction in the rat formalin test....
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Phenolic Contents, Enzyme Inhibitory Activities, and Protective Effect of Aqueous Extract of Rosa Pisiformis Fruits
The present study was designed to assess the phytochemical contents as well as the in vitro biological activities fruit of Rosa pisiformis and...
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Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons
BackgroundGuanfacine (an alpha-2A receptor agonist) is a commonly used drug with recognized efficacy in the treatment of attention deficit...
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Antidepressant and antinociceptive activities in animal models and in vitro assessment of the anti-thyroid activity of bis(DL-pyroglutamate) magnesium complex
BackgroundMagnesium is an essential element related with biochemistry of the brain and different types of depression have been associated with its...
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Grape Seed and Skin Extract Protects Against Doxorubicin Chemotherapy-Induced Oxidative Stress, Inflammation and Metabolic Enzyme Disturbances in Rat Lung
Doxorubicin (Doxo), a widely used antitumor anthracycline antibiotic, is the angular stone in the treatment of many neoplasic diseases though also...
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Features of Extracting Macroelements from Medicinal Plant Raw Materials Into Infusions and Decoctions
The features of extracting macroelements from medicinal plant raw materials (pharmacopoeial types) into infusions and decoctions were studied. The...
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Features of Accumulation of Macro- and Trace Elements by Medicinal Plant Raw Materials of Voronezh Region
The accumulation of macro- and trace elements by medicinal plant raw materials (MRMs) from soils in the natural biocenosis of Voronezh Region is...
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Effect of Ellipticine in Glucocorticoid-Induced Osteoporosis: In Silico and In Vivo Analyses
Glucocorticoids cause secondary osteoporosis, which leads to considerable morbidity from fractures. The antiosteoporosis activity of ellipticine...
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Prescriber responses to alternative alert builds (AABs) designed for enduring drug shortages: a descriptive study
ObjectiveOur objective was to assess how prescriber responses to drug-shortage-related alternative alert builds (AABs) changed over time during...
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Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model
BackgroundType 2 Diabetes Mellitus is a chronic metabolic disease that causes endothelial damage and is an important risk factor for atherosclerosis....
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Synthesis of Tertiary Piperazine Aminoalcohols and their Dihydrochlorides and their Influence on DNA Methylation Processes In Vitro
Tertiary piperazine aminoalcohols were synthesized by reacting 1-(4-butoxyphenyl)-3-(4-substituted piperazin-1-yl)-2-phenylpropan-1-ones with...
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Raw Materials
Raw materials for pharmaceutical preparations are either active substances (or active pharmaceutical ingredients (APIs)) or excipients. The choice of...
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Oral Liquids
Oral liquid medicines are a useful choice of dosage form for patients who have problems swallowing tablets and capsules. They are easily administered...
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Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels
BackgroundIn humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system...
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Synthesis and Antiaggregant and Anticoagulant Activity of Amino-Acid Salts and Computer Simulation of the Interaction of Their Structures with the Surface of Cyclooxygenase
Effective drugs with antiaggregant and anticoagulant activity are known to possess side effects. It was hypothesized that compounds synthesized from...
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Novel Potentiometric Sensor for the Determination of Ibuprofen
Apotentiometric ibuprofen-sensitive sensor with a plasticized poly(vinyl chloride) membrane was developed. The sensor contains an ionic associate of...
