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The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation
BackgroundMicroglia play a major role in the development of brain inflammation after central nervous system injury. On the other hand, microglia also...
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Pharmacological Strategies to Overcome Tumor Resistance to Anticancer Hormonal, Targeted, and Immunotherapy
Possible molecular mechanisms of develo** tumor drug resistance to anticancer hormonal, targeted, and immunotherapy that are associated with the...
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The role and application of transcriptional repressors in cancer treatment
Gene expression is modulated through the integration of many regulatory elements and their associated transcription factors (TFs). TFs bind to...
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The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer...
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Histone deacetylases (HDACs) as therapeutic target for depressive disorders
Major depressive disorder (MDD) represents approximately 40% of the disability caused by mental illnesses globally. The poorly understood...
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Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future
BackgroundDuchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular childhood disorder that causes progressive muscle weakness and...
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Targeting ROCK/LIMK/cofilin signaling pathway in cancer
Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase (LIMK)/cofilin-signaling cascades are stimulated by...
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Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade
Autophagy is a self-degradation process in which the cytoplasmic cargoes are delivered to the lysosomes for degradation. As the cargoes are...
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Barriers for Pharmaceutical Innovation With Focus in Cancer Drugs, the Case of Mexico
Drug innovation does not only generate economic growth but also portrays a country’s efforts toward innovation. The article reviews the current...
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Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against...
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Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance
Histone deacetylases (HDACs) regulate gene expression by creating the closed state of chromatin via histone hypoacetylation. Histone acetylation...
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Suppression of T cell functions by hydroxamic acid-based histone deacetylase inhibitors
Histone deacetylase inhibitors (HDACis) have recently been shown to suppress inflammatory responses at much lower concentrations than that the...
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An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with Mitomycin-C and a histone deacetylase inhibitor
This study was conducted to evaluate cytotoxicity due to co-treatment with low-dose Mitomycin-C (MMC) and the histone deacetylase inhibitor,...
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Pharmocoepigenetics: a new approach to predicting individual drug responses and targeting new drugs
Epigenetics is the study of heritable changes in genes and gene expression that do not involve DNAnucleotide sequences. Epigenetic modifications...