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Prolonged therapy with antidepressants increases hippocampal level of kynurenic acid and expression of Kat1 and Kat2 genes
BackgroundAccumulating data suggest an important role of disturbed kynurenine pathway and altered glutamatergic transmission in the pathogenesis of...
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Proteomic and transcriptomic analysis of lung tissue in OVA-challenged mice
Asthma is a long term inflammatory disease of the airway of lungs characterized by variable airflow obstruction and bronchospasm. Asthma is caused by...
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n-3 Fatty acids regulate the inflammatory-state related genes in the lung epithelial cells exposed to polycyclic aromatic hydrocarbons
BackgroundChronic airway inflammation is coordinated by a complex of inflammatory mediators, including eicosanoids. The aim of this study was to...
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Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes
Nuclear receptors such as aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), and constitutive androstane receptor (CAR) were first...
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Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study
BackgroundWe carried out a test whether or not transplant drugs such as cyclosporine A, Rapamycin (Sirolimus), Tacrolimus, Everolimus and...
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Emerging roles of orphan nuclear receptors in regulation of innate immunity
Innate immunity constitutes the first line of defense against pathogenic and dangerous insults. However, it is a double-edged sword, as it functions...
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Food, nutrients and nutraceuticals affecting the course of inflammatory bowel disease
Inflammatory bowel diseases (ulcerative colitis; Crohn’s disease) are debilitating relapsing inflammatory disorders affecting the gastrointestinal...
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Benzo(a)pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention
Lung cancer is the major cause of overall cancer deaths, and chemoprevention is a promising strategy to control this disease. Benzo(a)pyrene [B(a)P],...
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Nuclear factor E2-related factor-2 (Nrf2) expression and regulation in male reproductive tract
BackgroundNuclear factor E2-related factor-2 (Nrf2, Nfe2l2) plays an important, protective role in many tissues. However, information on molecular...
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Chemical biology approach for the development of hypoxia inducible factor (HIF) inhibitor LW6 as a potential anticancer agent
AbstractIntratumoral hypoxia has long been considered to be a driving force in tumor progression as well as a negative prognostic factor in human...
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TBBPA causes neurotoxic and the apoptotic responses in cultured mouse hippocampal neurons in vitro
BackgroundTetrabromobisphenol A (TBBPA) is a brominated flame retardant widely used in a variety of commercial and household products. TBBPA can...
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On the toxicity of kynurenic acid in vivo and in vitro
BackgroundKynurenic acid (KYNA), a tryptophan metabolite is an antagonist of ionotropic glutamate receptors and alpha-7 nicotinic receptor. Moreover,...
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Human Cytochrome P450 Enzymes
The cytochrome P450 (P450) enzymes first attracted interest because of their relevance to the metabolism of drugs, steroids, and carcinogens....
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Hormonal Regulation of Liver Cytochrome P450 Enzymes
Sex differences characterize hepatic expression of specific cytochrome P450 (CYP) enzymes and their associated CYP genes, and underlie the widespread...
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Microbial Cytochromes P450
The microbial P450s perform an array of oxidative and other chemical reactions that are both crucial for the viability of the bacterial, archaeal,...
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Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects
The theory of tumor immune surveillance states that the host immune system has means to recognize transformed cells and kills them to prevent growth...
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Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes
BackgroundOrganic cation transporter 1 (OCT1, SLC22A1) is a membrane transporter that is important for therapeutic effect of the antidiabetic drug...
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Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells
BackgroundKynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is an endogenous antagonist of α-7 nicotinic receptor...
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Experimental diabetes mellitus type 1 increases hippocampal content of kynurenic acid in rats
BackgroundDiabetes mellitus (DM) is frequently associated with peripheral and central complications and has recently emerged as a risk factor for...