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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing...
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Antioxidant Properties, Neuroprotective Effects and in Vitro Safety Evaluation of New Pyrrole Derivatives
The paper is focused on safety evaluation, antioxidant activity and neuroprotective properties determination of newly synthesized substituted...
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IN SILICO and IN VITRO Estimation of MAO-B Inhibitory Activity of Newly Synthesized Hydrazones Bearing a Pyrrole Heterocyclic System
This paper is focused on the in silico and in vitro determination of MAO-B inhibitory activity on recombinant MAO-B enzyme ( h MAOB) of newly...
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Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms
In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19...
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Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway
BackgroundNon-deleterious episodes of seizure preconditioning can efficiently increase the brain’s resistance to the consequent severe status...
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The protective effects of statins in traumatic brain injury
Traumatic brain injury (TBI), often referred to as the “silent epidemic”, is the most common cause of mortality and morbidity worldwide among all...
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ROCK Kinase Inhibitory Activity of Some Isoflavonoids and Their Pharmacological Significance in Glaucoma
Glaucoma is a chronic inflammatory disorder characterized by the loss of optic nerve fibers and the formation of retinopathy. The redox homeostasis...
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Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis
Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways involved in neurodegenerative disorders. Metformin, an...
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Alkaloids of Gnaphalium polycaulon with Anti-Alzheimer’s Activity
Three alkaloids were isolated from the aerial parts of Gnaphalium polycaulon Pers., Asteraceae, collected from San Juan Huancollo, Ingavi Province,...
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Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson’s disease
Parkinson’s disease (PD) is one of the most common serious neurodegenerative disorders in the world. The incidence of PD appears to be growing and...
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Advanced therapeutic strategies targeting microglia: beyond neuroinflammation
For a long time, microglia have been recognized as the main culprits of neuroinflammatory responses because they are primary phagocytes present in...
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The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation
BackgroundMicroglia play a major role in the development of brain inflammation after central nervous system injury. On the other hand, microglia also...
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Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor
BackgroundRecently, we have reported an isatin-derived carbohydrazone, 5-chloro-N'-(6-chloro-2-oxoindolin-3-ylidene)-2-hydroxybenzohydrazide ( SIH 3 )...
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Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol...
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Analysis of the Mechanisms of Action of a TSPO Ligand (GML-3 Compound) in a Model of Lipopolysaccharide-Induced Cell Damage
The ability of an 18-kDa translocator protein (TSPO) ligand, a pyrrolo[1,2- a ]pyrazine derivative, represented by N -butyl- N -methyl-1-phenylpyrrolo[1,2-
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Theories and Mechanism of Aging and Longevity Through Evolutionary Lens: a Coalition of Plant Anti-oxidants
The response to the dilemma behind “why do we age” and “what are major causes of aging” is inexplicable and it is tantamount to answer the most...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K
BackgroundThe phytocannabinoid cannabidiol (CBD) has previously shown to have anticonvulsant effects in preclinical and clinical studies. Recently,...
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Role of oxidative stress in epileptogenesis and potential implications for therapy
In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of “redox messengers”. In a state of oxidative...
