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BIOLOGICAL ACTIVITY OF COMPOUNDS OF PLANT ORIGIN
Due to their structural diversity and specific biological effects, natural substances play an important role in medication. Many of the medicines...
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Quercetin Simultaneously Inhibited Cytochrome P450 and P-Glycoprotein to Improve the Pharmacokinetics of Osthole in Rat Plasma
Plant-based medicines derived from traditional Chinese medicine have garnered widespread attention for their potential in the prevention and...
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Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway
Salvia miltiorrhiza Bunge, Lamiaceae, widely recognized as “danshen,” Chinese sage, is an important long-established traditional Chinese medication,...
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Journey from Serendipity to Biologics
The world today is largely focused on biologics-based treatment for many diseases as it is a very specific way to treat any disease and also happens...
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Medicinal and Therapeutic Properties of Ephedra
Ephedra is one of the oldest medicinal plants in traditional Chinese medicine for nearly 5000 years. The medicinal species are used as a stimulant...
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DEVELOPMENTS IN KNOWLEDGE ON ACTIVE COMPOUNDS OF NATURAL ORIGIN PHARMACOGNOSY IN THE 21ST CENTURY
The knowledge accumulated on the pharmacological properties of plants is a clear indication of the cultural and intellectual development of human...
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A Novel Case Study of the Use of Real-World Evidence to Support the Registration of an Osteoporosis Product in China
On June 23, 2020, Prolia ® (denosumab) was approved by the National Medical Products Administration (NMPA) in the People’s Republic of China as the...
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Assessment of the Antidiarrheal Activity and Chemical Composition of Dichloromethane Extract from Macleaya Cordata
Macleaya cordata (Willd.) R.Br., Papaveraceae, is a traditional Chinese herb, and it has been proven to have good antimicrobial, anti-inflammatory,...
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Eulophia Nuda: A Review of Its Traditional Uses, Phytochemistry and Pharmacology
Eulophia nuda Lindl. (Orchidaceae) is a small perennial terrestrial herb found in central and Southeast Asian regions usually known for its...
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Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review
The genus Tamarix in the Tamaricaceae family consists of more than 100 species of halophyte plants worldwide that are mainly used to improve...
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Structure-Activity Relationship and Pharmacological Evaluation of 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenylacetamide as Cholesterol Ester Transfer Protein Inhibitor
Cholesterol ester transfer protein is a plasma glycoprotein synthesized by the liver. Inhibitors of this protein have been researched to treat...
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All-round approaches to increase adverse drug reaction reports: a sco** review
IntroductionMedicines are among the most effective technologies for reducing mortality and morbidity. Adverse drug reactions (ADRs) are a...
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Therapeutic Proteins and Advanced Therapy Medicinal Products
This chapter is divided in two parts: Therapeutic proteins and Advanced Therapy Medicinal Products (ATMPs)....
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Trends and Characteristics of New Drug Approvals in China, 2011–2021
BackgroundIn the past decade, the Chinese drug regulatory system has undergone many changes. A major reform starting in 2015 has significantly...
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Longitudinal study of Good Pharmacy Practice roles covered at the annual world pharmacy congresses 2003–2019
BackgroundGlobally accepted roles of pharmacists are described in the Good Pharmacy Practice (GPP) standards, published by the World Health...
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Use of Real-World Evidence for Drug Regulatory Decisions in China: Current Status and Future Directions
Real-world data (RWD) and real-world evidence (RWE) have garnered great interest for supporting drug research and development (R&D) by medical...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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Integrated LC-MS/MS Method and Network Pharmacology for Exploring the Mechanism of Neuroprotective Effect of Ginsenoside Rc in Oxygen-Glucose Deprivation/Reperfusion Injury
Ginsenoside Rc is one of the active components of “nao-mai-tong,” which is a traditional Chinese medicine prescription widely used in the treatment...
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Using Bayesian Dynamic Borrowing to Maximize the Use of Existing Data: A Case-Study
Bayesian Dynamic Borrowing (BDB) designs are being increasingly used in clinical drug development. These methods offer a mathematically rigorous and...
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Boswellic Acid Nanoparticles: Promising Strategies for Increasing Therapeutic Effects
Boswellic acids, the main active compound found in the oleo-gum resin of Boswellia serrata Roxb., Burseraceae, have been used in traditional and...
