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Tumor-associated characteristics and immune dysregulation in nasopharyngeal carcinoma under the regulation of m7G-related tumor microenvironment cells
BackgroundNasopharyngeal carcinoma (NPC) is a type of malignant tumor with high morbidity. Aberrant levels of N7-methylguanosine (m7G) are closely...
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Selection of M7G-related lncRNAs in kidney renal clear cell carcinoma and their putative diagnostic and prognostic role
BackgroundKidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. This study aims to develop new biomarkers for...
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M7G-related molecular subtypes can predict the prognosis and correlate with immunotherapy and chemotherapy responses in bladder cancer patients
BackgroundN7-methylguanosine (m7G) is closely associated with tumor prognosis and immune response in many cancer types. The correlation between m7G...
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Expression patterns and prognostic value of key regulators associated with m7G RNA modification based on all gene expression in colon adenocarcinoma
BackgroundN7-methylguanosine (m7G) is present in a wide variety of organisms and has important roles. m7G has been reported to be involved in...
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The potential role of N7-methylguanosine (m7G) in cancer
N 7 -methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively...
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A comprehensive analysis of m6A/m7G/m5C/m1A-related gene expression and immune infiltration in liver ischemia–reperfusion injury by integrating bioinformatics and machine learning algorithms
BackgroundLiver ischemia–reperfusion injury (LIRI) is closely associated with immune infiltration, which commonly occurs after liver surgery,...
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A noval prognostic signature of the N7-methylguanosine (m7G)-related miRNA in lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) is characterized by high morbidity and mortality rates and poor prognosis. N7-methylguanosine play an...
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N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma
N7-methylguanosine (m7G) modification signature has recently emerged as a crucial regulator of tumor progression and treatment in cancer. However,...
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A new prediction model of hepatocellular carcinoma based on N7-methylguanosine modification
PurposeHepatocellular carcinoma (HCC) is a kind of primary liver cancer. It is a common malignant tumor of digestive system that is difficult to...
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Prognostic and immune implications of a novel 7-methylguanosine-related microRNA signature in breast invasive carcinoma: from exploration to validation
ObjectivesThis study aims to develop and validate a prognostic signature based on 7-methylguanosine-related (M7G-related) miRNAs for predicting...
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RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly...
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METTL1 gene polymorphisms synergistically confer hepatoblastoma susceptibility
IntroductionHepatoblastoma is a rare but devastating pediatric liver malignancy. Overexpressed methyltransferase-like 1 (METTL1) is a...
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A novel N7-methylguanosine-associated feature predicts prognosis in gastric cancer
BackgroundDespite substantial advancements in gastric cancer treatment in recent years, our understanding of the disease’s pathophysiology and...
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Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study
BackgroundNeuroblastoma (NB) is a common extracranial solid malignancy in children. The N7-methylguanosine (m 7 G) modification gene METTL1 / WDR4 ...
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Regulations of m6A and other RNA modifications and their roles in cancer
RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA...
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METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control
BackgroundRNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted...
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M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits its curative effect. Here,...
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METTL1/WDR4-mediated tRNA m7G modification and mRNA translation control promote oncogenesis and doxorubicin resistance
Osteosarcoma is the most common bone tumor that leads to high mortality in adolescents and children. The tRNA N 7 -methylguanosine methyltransferase...
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RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives
Malignant liver cancer is characterized by rapid tumour progression and a high mortality rate, whereas the molecular mechanisms underlying liver...
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M1A and m7G modification-related genes are potential biomarkers for survival prognosis and for deciphering the tumor immune microenvironment in esophageal squamous cell carcinoma
BackgroundEsophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in...
