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Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury
ObjectivesPrimary blast lung injury (PBLI) is the main cause of death in blast injury patients, and is often ignored due to the absence of a specific...
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Identification of the cuproptosis-related ceRNA network and risk model in acute ischemic stroke by integrated bioinformatics analysis
BackgroundAcute ischemic stroke (AIS) is one of the leading contributors to death and disability in adults. And cuproptosis is a novel type of cell...
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Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients
BackgroundJuvenile spondyloarthropathies (JSpA) are defined as a heterogeneous group of diseases that start before the age of 16. The study aimed to...
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Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis
BackgroundIncreasing evidence implicates circular RNAs (circRNAs) have been involved in human cancer progression. However, the mechanism remains...
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Exploration and bioinformatic prediction for profile of mRNA bound to circular RNA BTBD7_hsa_circ_0000563 in coronary artery disease
BackgroundAs a novel circRNA, BTBD7_hsa_circ_0000563 has not been fully investigated in coronary artery disease (CAD). Our aim is to reveal the...
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Identification of circRNA–miRNA–mRNA regulatory network associated to the autism spectrum disorder in children through integrated bioinformatics analysis
BackgroundAutism spectrum disorder (ASD) is a complex neurological disability with multifactorial etiology. ASD is described by behavior, speech,...
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Characterization of the circulating transcriptome expression profile and identification of novel miRNA biomarkers in hypertrophic cardiomyopathy
BackgroundHypertrophic cardiomyopathy (HCM), one of the most common genetic cardiovascular diseases, but cannot be explained by single genetic...
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Suppression of exosomal hsa_circ_0001005 eliminates the Vemurafenib resistance of melanoma
ObjectivesMore and more evidences show that circular RNAs (circRNAs) can be used as miRNA sponge to regulate the drug resistance of malignancies,...
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Construction of hub transcription factor–microRNAs–messenger RNA regulatory network in recurrent implantation failure
PurposeRecurrent implantation failure (RIF) affects up to 10% of in vitro fertilization (IVF) patients worldwide. However, the pathogenesis of RIF...
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Effects of hsa_circ_0074854 on colorectal cancer progression, construction of a circRNA–miRNA–mRNA network, and analysis of immune infiltration
PurposeCircular RNAs have been demonstrated to be closely associated with the onset and metastasis of colorectal cancer. However, the roles and...
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Mechanism of immune infiltration in synovial tissue of osteoarthritis: a gene expression-based study
BackgroundOsteoarthritis is a chronic degenerative joint disease, and increasing evidences suggest that the pathogenic mechanism involves immune...
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Transcriptome sequencing and microRNA–mRNA regulatory network construction in the lens from a Na2SeO3-induced Sprague Dawley rat cataract model
BackgroundA sight-threatening, cataract is a common degenerative disease of the ocular lens. This study aimed to explore the regulatory mechanism of...
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Potential biomarkers of aortic dissection based on expression network analysis
BackgroundAortic dissection (AD) is a rare disease with severe morbidity and high mortality. Presently, the pathogenesis of aortic dissection is...
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Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer
BackgroundThe altered long non-coding RNA (lncRNA), circular RNA (circRNA) and mRNA expression in triple-negative breast cancer (TNBC) after...
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CircRNAs in **ang pig ovaries among diestrus and estrus stages
BackgroundThe fecundity of sows is a trait of major economic in pig industry. The molecular regulation of estrus cycles can affect the fecundity of...
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Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration
BackgroundIntervertebral disc degeneration (IDD) has become a serious public health problem, the mechanism of which is complex and still unclear. We...
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Identification and verification of circRNA biomarkers for coronary artery disease based on WGCNA and the LASSO algorithm
BackgroundThe role of circular RNAs (circRNAs) as biomarkers of coronary artery disease (CAD) remains poorly explored. This study aimed to identify...
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Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China
BackgroundPolycystic ovary syndrome (PCOS) is a common reproductive, neuroendocrine, and metabolic disorder in women of reproductive age that affects...
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Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis
Recent studies have suggested that ferroptosis participates in various renal diseases. However, its effect on focal segmental glomerulosclerosis...
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Development and validation of a novel circular RNA as an independent prognostic factor in acute myeloid leukemia
BackgroundAlthough there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel and reliable biomarkers are still...
