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Evaluation of machine learning-based classification of clinical impairment and prediction of clinical worsening in multiple sclerosis
BackgroundRobust predictive models of clinical impairment and worsening in multiple sclerosis (MS) are needed to identify patients at risk and...
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Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy
BackgroundWhile many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this...
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Risk factors of worsening kidney function and mortality in patients with renal vein thrombosis: a retrospective study
BackgroundThe outcome of renal vein thrombosis, in particular as for the long-term impact on kidney function, is not fully known. We aimed to...
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A prediction model for worsening diabetic retinopathy after panretinal photocoagulation
BackgroundAs one of the severe complications of diabetes mellitus, diabetic retinopathy (DR) is the leading cause of blindness in the working age...
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Associations between cooking fuel use, its transitions, and worsening sensory impairments among Chinese middle-aged and older adults: a cohort study
BackgroundThis study aimed to explore the associations between household air pollution (HAP), measured by cooking fuel use, sensory impairments (SI),...
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Functional and structural brain MRI changes associated with cognitive worsening in multiple sclerosis: a 3-year longitudinal study
BackgroundHeterogeneous processes may contribute to cognitive impairment in multiple sclerosis (MS).
ObjectiveTo apply a longitudinal...
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Brain MRI activity during the year before pregnancy can predict long-term clinical worsening in patients with Multiple Sclerosis
BackgroundPregnancy has been observed to reduce the frequency of relapses in Multiple Sclerosis (MS) patients, but the relapse risk tends to increase...
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Association between triglyceride glucose index and worsening heart failure in significant secondary mitral regurgitation following percutaneous coronary intervention
BackgroundThe triglyceride glucose (TyG) index is an alternative to insulin resistance (IR) as an early indicator of worsening heart failure (HF)....
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Association of OCT and OCT angiography measures with the development and worsening of diabetic retinopathy in type 2 diabetes
ObjectiveTo assess if optical coherence tomography (OCT) and OCT angiography (OCTA) measures are associated with the development and worsening of...
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Development and validation of a community acquired sepsis-worsening score in the adult emergency department: a prospective cohort: the CASC score
BackgroundSepsis is a leading cause of death and serious illness that requires early recognition and therapeutic management to improve survival. The...
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Treatment Patterns, Outcomes, and Persistence to Newly Started Heart Failure Medications in Patients with Worsening Heart Failure: A Cohort Study from the United States and Germany
BackgroundData are limited regarding guideline-directed medical therapy (GDMT) treatment patterns in patients with worsening heart failure (HF).
...
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Nightshade Vegetables: A Dietary Trigger for Worsening Inflammatory Bowel Disease and Irritable Bowel Syndrome?
The Solanaceae family of plants, commonly known as Nightshade vegetables or Nightshades, contains a diverse range of crops of over 2000 members with...
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Low-molecular-weight heparin for the prevention of clinical worsening in severe non-critically ill COVID-19 patients: a joint analysis of two randomized controlled trials
Coronavirus disease 2019 (COVID-19) carries a high risk of vascular thrombosis. However, whether a specific anticoagulation intensity strategy may...
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Association between worsening renal function severity during hospitalization and low physical function at discharge: a retrospective cohort study of older patients with heart failure and chronic kidney disease from Japan
BackgroundThe number of hospitalized older patients with chronic heart failure, chronic kidney disease, and worsening renal function is rising in...
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Factors associated with worsening sexual function during adjuvant endocrine therapy in a prospective clinic-based cohort of women with early-stage breast cancer
PurposeSexual function problems are common but under-reported among women receiving adjuvant endocrine therapy for breast cancer. Worsening scores on...
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Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
BackgroundOxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free...
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Deep brain stimulation of the subthalamic nucleus in severe Parkinson’s disease: relationships between dual-contact topographic setting and 1-year worsening of speech and gait
BackgroundSubthalamic nucleus (STN) deep brain stimulation (DBS) alleviates severe motor fluctuations and dyskinesia in Parkinson’s disease, but may...
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Increased cannabis intake during the COVID-19 pandemic is associated with worsening of depression symptoms in people with PTSD
BackgroundSome evidence suggests substance use affects clinical outcomes in people with posttraumatic stress disorder (PTSD). However, more work is...
