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Schizophrenia and risk preference: a bidirectional two-sample mendelian randomization study
Increasing evidence shows that risk preference is associated with schizophrenia. However, the causality and direction of this association are not...
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Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study
IntroductionRecent studies have suggested a potential association between methotrexate use and an increased risk of dementia. However, the causal...
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Diabetes and osteoporosis: a two-sample mendelian randomization study
BackgroundThe effects on bone mineral density (BMD)/fracture between type 1 (T1D) and type 2 (T2D) diabetes are unknown. Therefore, we aimed to...
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Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study
BackgroundObservational studies have suggested that type 2 Diabetes Mellitus (DM2) is a potentially modifiable risk factor for lower BMD, but the...
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Association between leptin and NAFLD: a two-sample Mendelian randomization study
BackgroundThe etiology of nonalcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors. Previous...
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Gut microbiota and chronic rhinosinusitis: a two-sample Mendelian randomization study
BackgroundThe nasal cavity and gut are interconnected, both housing a rich natural microbiome. Gut microbiota may interact with nasal microbiota and...
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The role of circulating metabolites and gut microbiome in hypertrophic scar: a two-sample Mendelian randomization study
Hypertrophic scarring is a fibro-proliferative disorder caused by abnormal cutaneous wound healing. Circulating metabolites and the gut microbiome...
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Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization
BackgroundHelicobacter pylori (H. pylori), according to a number of recent observational studies, is connected to atherosclerosis (AS). However, the...
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Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization
Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of...
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Causal associations of Insomnia and postpartum depression: a two-sample mendelian randomization study
BackgroundPostpartum depression (PPD), a prevalent social-mental condition, impacts the mother and the newborn and several facets of their lives. It...
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Epilepsy and childhood psychiatric disorders: a two-sample bidirectional Mendelian randomization study
BackgroundObservational studies have indicated that psychiatric disorders are the most common comorbidities in pediatric epilepsy. However, the...
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Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study
BackgroundAlthough previous studies have suggested a close association between gut microbiota (GM) and intervertebral disc degeneration (IVDD), the...
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Causal effects of gut microbiome on HIV infection: a two-sample mendelian randomization analysis
BackgroundThe causal association between gut microbiome and HIV infection remains to be elucidated. We conducted a two-sample mendelian randomization...
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Basal metabolic rate and the risk of urolithiasis: a two-sample Mendelian randomization study
ObjectiveFew studies have investigated the impact of basal metabolic rate (BMR) on the development of urolithiasis, and the causal relationship is...
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Causal impact of statins on susceptibility to osteoarthritis: insights from a two-sample Mendelian randomization analysis
BackgroundOsteoarthritis is a widely prevalent cause of pain and disability among older adults. It is an incurable condition, and most treatments are...
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Vitamin D and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study
BackgroundA prospective study of multiple small samples found that idiopathic pulmonary fibrosis (IPF) is often accompanied by a deficiency in...
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Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study
Background and AimsPrimary aldosteronism (PA) is an adrenal disorder of autonomous aldosterone secretion which promotes arterial injury. We aimed to...
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Causal relationships between obesity and pancreatobiliary diseases: a two-sample Mendelian randomization study
Previous observational studies have investigated the relationship between obesity and the biliary tract and pancreas. The causality, however, is...
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Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study
BackgroundThe causal relationship and the direction of the effect between depression and aging remain controversial.
MethodsWe used a bidirectional...
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Causal relationships between delirium and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study
BackgroundPrevious observational studies have suggested a notably elevated prevalence of delirium in individuals diagnosed with Parkinson’s disease...
