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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite...
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MTDH-stabilized DDX17 promotes tumor initiation and progression through interacting with YB1 to induce EGFR transcription in Hepatocellular Carcinoma
Metadherin (MTDH) is a well-established oncogene in various cancers including Hepatocellular Carcinoma (HCC). However, the precise mechanism through...
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Letter to the Editor Regarding Article “Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset”
The cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI...
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Clinical impact of delaying initiation of adjuvant chemotherapy in patients with early triple negative breast cancer
PurposeThe optimal time to initiation of adjuvant chemotherapy (TTAC) for triple negative breast cancer (TNBC) patients is unclear. This study...
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Integrating a Disease-Focused Tumor Board as a Delivery-of-Care Model to Expedite Treatment Initiation for Patients With Liver Malignancies
BackgroundPatients with hepatobiliary malignancies are especially vulnerable to treatment delays. This study sought to evaluate the impact of...
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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be...
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Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma
BackgroundLenvatinib, a multiple receptor tyrosine kinase inhibitor, might exert antitumor effects via tumor immune modulation. However, changes in...
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Massively recruited sTLR9+ neutrophils in rapidly formed nodules at the site of tumor cell inoculation and their contribution to a pro-tumor microenvironment
Neutrophils exert either pro- or anti-tumor activities. However, few studies have focused on neutrophils at the tumor initiation stage. In this...
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Racial disparities in initiation of chemotherapy among breast cancer patients with discretionary treatment indication in the state of Georgia
PurposeThe majority of breast cancer patients are diagnosed with early-stage estrogen receptor (ER) positive disease. Despite effective treatments...
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Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression
Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME)....
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The role of tumor-associated macrophages in tumor immune evasion
BackgroundTumor growth is closely linked to the activities of various cells in the tumor microenvironment (TME), particularly immune cells. During...
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Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma
BackgroundEsophagectomy is the main treatment for esophageal squamous cell carcinoma (ESCC), and patients with histopathologically negative margins...
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Impact on Survival of Early Versus Late Initiation of Adjuvant Chemotherapy After Pancreatic Adenocarcinoma Surgery: A Target Trial Emulation
BackgroundWe examined the impact of early (0–4 weeks after discharge) versus late (> 4–8 weeks after discharge) initiation of adjuvant chemotherapy...
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Forming cytoplasmic stress granules PURα suppresses mRNA translation initiation of IGFBP3 to promote esophageal squamous cell carcinoma progression
Esophageal squamous cell carcinoma (ESCC) is one of the most fatal malignancies worldwide. Recently, our group identified purine-rich element binding...
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Tumor lysis syndrome in induction therapy for acute myeloid leukemia before the rasburicase era
Guidelines recommend rasburicase for high-risk patients to prevent tumor lysis syndrome (TLS). However, little information is available on the...
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Tumor-associated characteristics and immune dysregulation in nasopharyngeal carcinoma under the regulation of m7G-related tumor microenvironment cells
BackgroundNasopharyngeal carcinoma (NPC) is a type of malignant tumor with high morbidity. Aberrant levels of N7-methylguanosine (m7G) are closely...
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Socioeconomic equality in initiation of biologic treatment in Danish patients with inflammatory bowel disease
BackgroundLow socioeconomic status is associated with disadvantages in health outcomes and delivery of medical care in patients with Inflammatory...
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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression. A tumor subpopulation called liver cancer...
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Benefit and risk of oral anticoagulant initiation strategies in patients with atrial fibrillation and cancer: a target trial emulation using the SEER-Medicare database
Oral anticoagulants (OACs) are recommended for patients with atrial fibrillation (AFib) having CHA 2 DS 2 -VASc score ≥ 2. However, the benefits of OAC...
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Exploiting docetaxel-induced tumor cell necrosis with tumor targeted delivery of IL-12
There is strong evidence that chemotherapy can induce tumor necrosis which can be exploited for the targeted delivery of immuno-oncology agents into...
