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The impact of tubular dysfunction and its relationship with acute kidney injury in children
BackgroundTubular dysfunction can cause electrolyte disturbances with potentially serious consequences. We studied the epidemiology and outcomes of...
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Tubulopathy meets Sherlock Holmes: biochemical fingerprinting of disorders of altered kidney tubular salt handling
Evolution moves in mysterious ways. Excretion of waste products by glomerular filtration made perfect sense when life evolved in the ocean. Yet, the...
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Renal Tubular Acidosis in Children New Insights in Diagnosis and Treatment
This book is a compilation of scientific knowledge regarding the clinical entity known as “Renal Tubular Acidosis in Children” (RTA). It contains the...
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The pathophysiology of distal renal tubular acidosis
The kidneys have a central role in the control of acid–base homeostasis owing to bicarbonate reabsorption and production of ammonia and ammonium in...
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Genetic diagnosis and treatment of hereditary renal tubular disease with hypokalemia and alkalosis
Renal tubules play an important role in maintaining water, electrolyte, and acid–base balance. Renal tubule dysfunction can cause electrolyte...
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Kidney tubular injury induced by valproic acid: systematic literature review
BackgroundValproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. It has also been implicated as a...
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Distal renal tubular acidosis as a rare complication of vesicoureteral reflux in children: a case report and literature review
Distal renal tubular acidosis (dRTA) is a clinical picture of hyperchloremic hypokalemic metabolic acidosis with a normal anion gap. It can be caused...
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Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p
ObjectiveDiabetic nephropathy (DN) manifests a critical aspect in the form of renal tubular injury. The current research aimed to determine the...
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The value of kidney biochemical parameters in diagnosis of acute tubular necrosis (ATN) in chickens
Acute tubular necrosis (ATN) is one of the main causes of acute renal failure of kidney origin. This state can be caused by the increase in the use...
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Functional analysis reveals calcium-sensing receptor gene regulating cell–cell junction in renal tubular epithelial cells
PurposeCalcium-sensing receptor (CASR) influences the expression pattern of multiple genes in renal tubular epithelial cells. The objective of this...
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Septic Shock, Tubular Necrosis, and Central Diabetes Insipidus: A Challenging Syndrome
BackgroundThe association between septic shock, acute tubular necrosis, and central diabetes insipidus is infrequent: our recent clinical observation...
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Apoptosis in lupus nephritis patients: a study of Bcl-2 to assess glomerular and tubular damage
BackgroundSystemic lupus erythematosus (SLE) is an immune-mediated disease, due to exposure of self-antigens, through impairment of apoptosis and...
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Nanocrystal-induced chronic tubular-nephropathy in tropical countries: diagnosis, mitigation, and eradication
In tropical countries, a mysterious tubulo-interstitial chronic renal disease (CKD), unrelated to diabetes, hypertension, and immunological causes,...
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Moyamoya disease presenting with tubular dysfunction in a child: pitfalls in diagnosing an atypical hyponatremic-hypertensive syndrome
BackgroundMoyamoya disease, a cause of pediatric stroke, has been shown to affect furthermore extra-cranial districts, mostly the kidney arterial...
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β-Thalassemia minor & renal tubular dysfunction: is there any association?
ObjectiveBeta(β)-thalassemia is one of the most common hereditary hematologic disorders. Patients with thalassemia minor (TM) are often asymptomatic...
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HMGN1 down-regulation in the diabetic kidney attenuates tubular cells injury and protects against renal inflammation via suppressing MCP-1 and KIM-1 expression through TLR4
BackgroundRenal tubular injury, accompanied by damaging inflammation, has been identified to drive diabetic kidney disease (DKD) toward end-stage...
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Assessing early tubular protective effects of SGLT2 inhibitor empagliflozin against type 2 diabetes mellitus using functional magnetic resonance imaging
AimsTo observe the alterations in functional magnetic resonance imaging parameters in normoalbuminuric type 2 diabetic patients undergoing SGLT2...
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Long-term complications of primary distal renal tubular acidosis
The clinical manifestations of primary distal renal tubular acidosis usually begin in childhood, but the disease is caused by a genetic defect that...
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FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury
Acute kidney injury (AKI) is a serious clinical complication with high morbidity and mortality rates. Despite substantial progress in understanding...
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Immunometabolic rewiring of tubular epithelial cells in kidney disease
Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response to acute and chronic injury. To adequately respond to...
