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The immunohistochemical expression of von Willebrand factor, T-cadherin, and Caveolin-1 is increased in kidney allograft biopsies with antibody-mediated injury
BackgroundThere are only a few reports evaluating the applicability of endothelial-damage markers analysis by immunohistochemistry (IHC) in kidney...
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CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
BackgroundCDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer...
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High core 1β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
PurposeCore 1β1,3-galactosyltransferase 1 (C1GALT1) exhibits elevated expression in multiple cancers. The present study aimed to elucidate the...
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Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer
MARCH7 is an E3 ubiquitin ligase known to regulate neuronal development,T-cell proliferation, and cell and tissue differentiation. But, the altered...
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Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer
BackgroundVasculogenic mimicry (VM), an alternative microvascular circulation independent of angiogenesis, is formed by aggressive cancer cells....
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Analysis of tumor microenvironment alterations in partially responsive rectal cancer patients treated with neoadjuvant chemoradiotherapy
PurposeAchieving a pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) remains a challenge for most patients with rectal...
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Cauda equina neuroendocrine tumors show biological features distinct from other paragangliomas and visceral neuroendocrine tumors
Cauda equina neuroendocrine tumors (CENETs) are neoplasms of uncertain histogenesis with overlap** features between those of paragangliomas (PGs)...
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Targeting CDH17 with Chimeric Antigen Receptor-Redirected T Cells in Small Cell Lung Cancer
BackgroundChimeric antigen receptor T cell (CAR-T) therapy stands as a precise and targeted approach in the treatment of malignancies. In this study,...
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Relaxin combined with transarterial chemoembolization achieved synergistic effects and inhibited liver cancer metastasis in a rabbit VX2 model
ObjectiveTo explore the effect and mechanism of relaxin (RLX) in the growth and metastasis of livercancer after combination treatment with...
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Acupuncture and Moxibustion Inhibited Intestinal Epithelial-Mesenchymal Transition in Patients with Crohn’s Disease Induced by TGF- β 1/Smad3/Snail Pathway: A Clinical Trial Study
ObjectiveTo explore whether acupuncture combined with moxibustion could inhibit epithelialmesenchymal transition in Crohn’s disease by affecting the...
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Epstein–Barr virus positive gastric cancer: the pathological basis of CT findings and radiomics models prediction
PurposeTo analyze the clinicopathologic information and CT imaging features of Epstein–Barr virus (EBV)-positive gastric cancer (GC) and establish...
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SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma
The histogenesis of pleomorphic adenoma (PA) of the salivary glands remains controversial. PAs are characterized by the transition of epithelial...
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Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma
Oral squamous cell carcinoma (named OSCC) is considered the most frequent malignancy in oral cavity, which has become a rapid increasing problem for...
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Hepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment
Background and purposeWhile HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. To evaluate the...
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MicroRNA Signature and Cellular Characterization of Undifferentiated and Differentiated House Ear Institute-Organ of Corti 1 (HEI-OC1) Cells
MicroRNAs (miRNAs) regulate gene expressions and control a wide variety of cellular functions. House Ear Institute-Organ of Corti 1 (HEI-OC1) cells...
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Placental-Cadherin, a biomarker for local immune status and poor prognosis among patients with tongue squamous cell carcinoma
BackgroundThe prognostic and clinicopathological value of placental-Cadherin (CDH3) in multiple cancers is controversial. The diagnostic significance...
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RAGE mediates airway inflammation via the HDAC1 pathway in a toluene diisocyanate-induced murine asthma model
BackgroundExposure to toluene diisocyanate (TDI) is a significant pathogenic factor for asthma. We previously reported that the receptor for advanced...
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Loss of ARID1A expression is associated with systemic inflammation markers and has important prognostic significance in gastric cancer
BackgroundThe tumor suppressor gene AT-rich interactive domain 1A ( ARID1A ) and systemic inflammatory response (SIR) have been reported to be related...
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Cadherin-17 as a target for the immunoPET of adenocarcinoma
PurposeCadherin-17 (CDH17) is a calcium-dependent cell adhesion protein that is overexpressed in several adenocarcinomas, including gastric,...
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Immune parameters of HIV susceptibility in the female genital tract before and after penile-vaginal sex
BackgroundIn women, most HIV infections are acquired through penile-vaginal sex. Inflammation in the female genital tract (FGT) increases the risk of...
