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The 2022 International League Against Epilepsy Classification and Definition of Childhood Epilepsy Syndromes: An Update for Pediatricians
The 2017 classification of the epilepsies of International League Against Epilepsy (ILAE) defined three diagnostic levels, including seizure type,...
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Deep phenoty** of frontal lobe epilepsy compared to other epilepsy syndromes
AimsFrontal lobe epilepsy (FLE) is understudied and often misdiagnosed. We sought to comprehensively phenotype FLE and to differentiate FLE from...
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Disparities in pediatric drug-resistant epilepsy care
IntroductionEpilepsy affects millions of children worldwide, with 20–40% experiencing drug-resistant epilepsy (DRE) who are recommended for epilepsy...
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Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy—A Pilot Study
PurposeIndividuals with drug-resistant epilepsy may benefit from epilepsy surgery. In nonlesional cases, where no epileptogenic lesion can be...
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Genetics and genetic diagnosis of focal childhood epilepsy
Self-limiting focal epilepsies are among the most common forms of epilepsy in children. Based on family studies, a genetic basis is assumed for the...
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Improvement of epilepsy secondary to acquired immunodeficiency syndrome with intestinal microbiota preparations: a case report
BackgroundEpilepsy secondary to acquired immunodeficiency syndrome (AIDS) can be challenging to manage. The potential interactions between...
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Re-evaluating the placebo response in recent canine dietary epilepsy trials
The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can...
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A review of cell-type specific circuit mechanisms underlying epilepsy
Epilepsy is a prevalent neurological disorder, yet its underlying mechanisms remain incompletely understood. Accumulated studies have indicated that...
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Epilepsy surgery in pediatric refractory status epilepticus
The mainstay of status epilepticus (SE) treatment is pharmacotherapy with anti-seizure medications (ASM). In refractory status epilepticus (RSE),...
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Outcomes of stereoelectroencephalography following failed epilepsy surgery in children
IntroductionStereoelectroencephalography (SEEG) is valuable for delineating the seizure onset zone (SOZ) in pharmacoresistant epilepsy when...
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Further advances in epilepsy
In 2017, one of us reviewed advances in epilepsy (Manford in J Neurol 264:1811–1824, 2017). The current paper brings that review up to date and gives...
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microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients
BackgroundAlthough previous studies show that microRNAs (miRNAs) can potentially be used as diagnostic markers for epilepsy, there are very few...
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EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy
Epilepsy is one of the most frequent neurological conditions with an estimated prevalence of more than 50 million people worldwide and an annual...
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Low-grade glioma of the temporal lobe and tumor-related epilepsy in children
PurposeLow-grade glioma is the most common brain tumor among children and adolescents. When these tumors arise in the temporal lobe, patients...
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Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy
Increasing evidence indicate that neuroinflammation triggered by glial cells plays a significant role in epileptogenesis. To this effect, the...
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P300 event-related potentials in people with epilepsy: clinico-neurophysiologic study
BackgroundThere is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment (CI) in memory, attention,...
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A case of migraine misdiagnosed as epilepsy
BackgroundMigraine and epilepsy are both episodic disorders, with some overlap** symptoms, mechanisms and therapies. Clinically, there is a...
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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition...
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Disruption of EEG resting state functional connectivity in patients with focal epilepsy
BackgroundEpilepsy is a network disease and EEG could be used to evaluate dynamic inter-regional connectivity. The aim of the current study is to...
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Managing delayed or missed pregabalin doses in patients with focal epilepsy: a Monte Carlo simulation study
BackgroundDelayed or missed doses are inevitable in epilepsy pharmacotherapy. The current remedial measures recommended by the United States Food and...
