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An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant
Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors. Recent evidence has demonstrated the importance of...
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Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles
BackgroundIncreased maternal interleukin (IL)-17A and activated microglia are pivotal factors contributing to the pathological phenotypes of maternal...
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Interleukin (IL)-17A in triple-negative breast cancer: a potent prognostic factor associated with intratumoral neutrophil infiltration
BackgroundTriple-negative breast cancer (TNBC) is characterized as highly immunogenic and lacks specific targeted therapies. Interleukin 17A (IL-17A)...
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Interleukin-17A Inhibitors in Patients with Psoriasis and Tuberculosis Infection: A 2-Year Prospective Study on Safety Without Preventive Treatment
IntroductionThe necessity for tuberculosis preventive treatment (TPT) and routine T-SPOT.TB monitoring in patients with psoriasis and tuberculosis...
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Speed and Cumulative Responses According to Body Regions in Patients with Moderate-to-Severe Plaque Psoriasis Treated with Ixekizumab (Interleukin-17A Antagonist) versus Guselkumab (Interleukin-23p19 Inhibitor)
IntroductionWhen assessing the effect of a therapy for psoriasis (PsO), it is important to consider speed of response and cumulative response....
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Reliability, stability during long-term storage, and intra-individual variation of circulating levels of osteopontin, osteoprotegerin, vascular endothelial growth factor-A, and interleukin-17A
BackgroundStudies in many populations have reported associations between circulating cytokine levels and various physiological or pathological...
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Potential gastrointestinal Behcet’s disease flare after treatment with anti-interleukin 17a therapy
BackgroundBehcet’s disease (BD) is a systemic disease characterized by recurrent oral and genital ulcers. The underlying disease pathway likely...
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Interleukin 17A: Key Player in the Pathogenesis of Hypertension and a Potential Therapeutic Target
Purpose of ReviewTo summarize key advances in our understanding of the role of interleukin 17A (IL-17A) in the pathogenesis of hypertension and...
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Efficacy and safety of interleukin-17A inhibitors in patients with ankylosing spondylitis: a systematic review and meta-analysis of randomized controlled trials
To assess the efficacy and safety of interleukin (IL)-17A inhibitors in patients with ankylosing spondylitis (AS). PubMed, EMBASE, and Web of Science...
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Role of Interleukin 17A in Aortic Valve Inflammation in Apolipoprotein E-deficient Mice
Interleukin 17A (IL17A) is reported to be involved in many inflammatory processes, but its role in aortic valve diseases remains unknown. We examined...
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Plasma interleukin-23 and circulating IL-17A+IFNγ+ ex-Th17 cells predict opposing outcomes of anti-TNF therapy in rheumatoid arthritis
ObjectivesTNF-α inhibitors are widely used in rheumatoid arthritis (RA) with varying success. Response to TNF-α inhibition may reflect the evolution...
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MicroRNA-151 Attenuates Apoptosis of Endothelial Cells Induced by Oxidized Low-density Lipoprotein by Targeting Interleukin-17A (IL-17A)
Apoptosis of endothelial cells plays an important role in atherosclerosis (AS). MicroRNAs (miRNAs) have been confirmed to participate in the process...
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Increased interleukin-17A-producing γδT cells predict favorable survival in elderly patients with LUAD and LUSC
PurposeAging is closely related to the occurrence of many diseases, including cancer, and involves changes in the immune microenvironment. γδT cells...
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Interleukin-1β, interleukin-6, and interleukin-17A as indicators reflecting clinical response to celecoxib in ankylosing spondylitis patients
BackgroundThis study was to investigate the value of 10 serum inflammatory cytokines for predicting clinical response to celecoxib in ankylosing...
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Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination
ObjectivesInterleukin-17A (IL-17A) is pro-inflammatory cytokine and acts as profibrotic factor in the fibrosis of various organs. Fibrosis tumor-like...
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Interleukin-17 as a biomarker for lupus nephritis: correlation with disease activity indices and histopathological classification
BackgroundLupus nephritis (LN) is one of the devastating manifestations of systemic lupus erythematosus (SLE). It is a leading cause of death in SLE...
