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Reproducibility of heart rate recovery measures across differing modalities and intensities of submaximal exercise in healthy volunteers: A healthy volunteer study
PurposeSubmaximal exercise tests (SET) are an easier to conduct and less physically demanding alternative to cardiopulmonary exercise testing for...
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Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers
Background and ObjectiveDeficiencies of enzymes acting downstream of glucosylceramide synthase (GCS) can cause severe substrate accumulation....
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral AL01211 in Healthy Chinese Volunteers
Background and ObjectiveAberrant accumulation of glycosphingolipids (GSLs) in the lysosome leads to GSL storage diseases. Glucosylceramide synthase...
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Repeatability of deuterium metabolic imaging of healthy volunteers at 3 T
BackgroundMagnetic resonance (MR) imaging of deuterated glucose, termed deuterium metabolic imaging (DMI), is emerging as a biomarker of...
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Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers
Background and ObjectiveTucatinib is a selective tyrosine kinase inhibitor of the human epidermal growth factor receptor 2 (HER2) approved to treat...
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Photobiomodulation enhanced endogenous pain modulation in healthy volunteers
To examine the effects of photobiomodulation (PBM) in healthy volunteers using photonic stimulation of acupuncture points on conditioned pain...
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Safety, Tolerability, and Pharmacokinetics of Oral BI 1358894 in Healthy Japanese Male Volunteers
Background and ObjectivesBI 1358894, a novel small-molecule inhibitor of transient receptor potential canonical ion channels, is under development...
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Unveiling the Influence of a High-Fat Meal on the Pharmacokinetics of Oral Globalagliatin, A Glucokinase Activator, in Healthy Chinese Volunteers
IntroductionGlucokinase (GK) plays a pivotal role in maintaining glucose homeostasis; globalagliatin, a newly developed drug, is a GK activator...
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Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study
IntroductionKukoamine B (KB) is a novel sepsis therapeutic drug targeting lipopolysaccharide and CpG DNA. This study aims to evaluate the safety,...
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Endocannabinergic modulation of central serotonergic activity in healthy human volunteers
BackgroundThe serotonergic and the endocannabinoid system are involved in the etiology of depression. Depressive patients exhibit low serotonergic...
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Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study
Several studies of the effects on cognition of selective serotonin reuptake inhibitors (SSRI), administered either acutely or sub-chronically in...
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Reconstruction of 3D knee MRI using deep learning and compressed sensing: a validation study on healthy volunteers
BackgroundTo investigate the potential of combining compressed sensing (CS) and artificial intelligence (AI), in particular deep learning (DL), for...
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An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers
BackgroundPosaconazole is widely used for the prophylaxis and treatment of invasive fungal diseases. Because of the limited and variable absorption...
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Bioequivalence Study of Two Tablet Formulations of Clonazepam 2 mg: A Randomized, Open-Label, Crossover Study in Healthy Mexican Volunteers Under Fasting Conditions
IntroductionThe prevalence of neurological disorders is high among the Mexican population. Clonazepam is primarily indicated to treat panic...
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The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers
Background and ObjectiveThere is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants....
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Lax Uterosacral Ligament and Urge Urinary Incontinence: MRI Findings in Symptomatic Patients Versus Healthy Volunteers
Introduction and hypothesisThe objective was to explore the association between urge urinary incontinence (UUI) and lax uterosacral ligaments (USL)...
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Is gallbladder PoCUS diagnostic accuracy accessible to medical students after PoCUS training exclusively on healthy volunteers? A pilot randomized control trial
BackgroundPoint-of-care ultrasound (PoCUS) is increasingly used in clinical practice and is now included in many undergraduate curricula. Here, we...
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Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
BackgroundTrauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the...
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Relative Bioavailability of Dolutegravir (DTG) and Emtricitabine/Tenofovir Alafenamide Fumarate (F/TAF) Administered as Paediatric Tablet Formulations in Healthy Volunteers
Background and objectiveWithin the UNIVERSAL project (RIA2019PD-2882) we aim to develop a paediatric dolutegravir (DTG)/emtricitabine (FTC or...
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Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial
IntroductionPsoriasis is a common skin disorder associated with physical and psychological burdens. Visible disfiguration can trigger a negative...
