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Deep learning for automatic diagnosis of gastric dysplasia using whole-slide histopathology images in endoscopic specimens
BackgroundDistinguishing gastric epithelial regeneration change from dysplasia and histopathological diagnosis of dysplasia is subject to...
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Prognostic importance of mitosis quantification and PHH3 expression in oral epithelial dysplasia
Oral epithelial dysplasia (OED) is diagnosed and graded using a range of histological features, making grading subjective and challenging. Mitotic...
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Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia
PurposeThe mechanism underlying malignant transformation of vocal fold leukoplakia (VFL) and the precise role of the expression of pepsin in VFL...
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A case of pyloric gland adenoma with high-grade dysplasia in the duodenum arising from heterotopic gastric mucosa observed over 5 years
Pyloric gland adenoma (PGA) in the duodenum is a rare gastric phenotype duodenal neoplasm. Although heterotopic gastric mucosa in the duodenum has...
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Epstein-Barr virus associated gastric dysplasia: a new rare entity?
Epstein-Barr virus (EBV) infection characterizes a portion of gastric adenocarcinomas. However, since there is lack of evidence of EBV presence in...
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The updated WHO classification of digestive system tumours—gastric adenocarcinoma and dysplasia
The fifth edition of the World Health Organization (WHO) classification of digestive system tumours was published in 2019. The classification of...
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Molecular subty** of gastroesophageal dysplasia heterogeneity according to TCGA/ACRG classes
Gastric adenocarcinoma has recently been classified into several subtypes on the basis of molecular profiling, which has been successfully reproduced...
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Endoscopic resection of gastric low-grade dysplasia with high risk factors is associated with decreased advanced neoplasia: a single-center retrospective cohort study
BackgroundThe natural course of gastric low-grade dysplasia (LGD) remains unclear, and there are inconsistent management recommendations among...
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FTO-mediated m6A modification promotes malignant transformation of gastric mucosal epithelial cells in chronic Cag A+ Helicobacter pylori infection
ObjectivesCag A + Helicobacter pylori chronic infection cause malignant transformation of the human gastric mucosa. N6-methyladenosine (m 6 A)...
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Gastric microbiome signature for predicting metachronous recurrence after endoscopic resection of gastric neoplasm
BackgroundChanges in gastric microbiome are associated with gastric carcinogenesis. Studies on the association between gastric mucosa-associated...
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PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment
BackgroundPeroxisome proliferator-activated receptor delta (PPARδ) promotes inflammation and carcinogenesis in many organs, but the underlying...
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Revolutionizing Gastric Cancer Prevention: Novel Insights on Gastric Mucosal Inflammation-Cancer Transformation and Chinese Medicine
The progression from gastric mucosal inflammation to cancer signifies a pivotal event in the trajectory of gastric cancer (GC) development. Chinese...
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Prevalence of Extensive and Limited Gastric Intestinal Metaplasia and Progression to Dysplasia and Gastric Cancer
Background and AimsGuidelines cite extensive gastric intestinal metaplasia (GIM) as a bigger risk factor for gastric cancer (GC) than limited GIM and...
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CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors
BackgroundMucosal gastric atrophy and intestinal metaplasia (IM) increase the risk for the development of gastric cancer (GC) as they represent a...
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SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review
Undifferentiated gastric carcinoma, characterized by anaplastic cells lacking distinct features of cytological or architectural differentiation,...
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Gastric villous adenoma: a case report and review of the literature
BackgroundVillous adenoma is the one subtype of adenomatous polyp that is very uncommon in the stomach. Data regarding clinical characteristics,...
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Analysis of factors associated with local recurrence after endoscopic resection of gastric epithelial dysplasia: a retrospective study
BackgroundEndoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely used techniques for the treatment of gastric...
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The occurrence, progression and development of four types of gastric mucosal atrophic lesions and their histopathological characteristics
ObjectiveTo investigate the occurrence and development of gastric mucosal atrophic lesions and their histopathological characteristics.
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Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -naïve patients: a multicenter retrospective analysis
BackgroundThe incidence of gastric neoplasms in Helicobacter pylori (Hp) -naïve patients has recently increased due to a remarkable decrease in the Hp ...
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Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach
BackgroundGastric precancerous lesions are a critical stage in the development of gastric cancer or gastric adenocarcinoma, and their outcome plays...
