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Genetics and genetic diagnosis of focal childhood epilepsy
Self-limiting focal epilepsies are among the most common forms of epilepsy in children. Based on family studies, a genetic basis is assumed for the...
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The impact of referring patients with drug-resistant focal epilepsy to an epilepsy center for presurgical diagnosis
BackgroundEpilepsy surgery is an established treatment for drug-resistant focal epilepsy (DRFE) that results in seizure freedom in about 60% of...
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Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy—A Pilot Study
PurposeIndividuals with drug-resistant epilepsy may benefit from epilepsy surgery. In nonlesional cases, where no epileptogenic lesion can be...
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Yield of non-invasive imaging in MRI-negative focal epilepsy
ObjectiveThe absence of MRI-lesion reduces considerably the probability of having an excellent outcome (International League Against Epilepsies...
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Genetics of nonlesional focal epilepsy in adults and surgical implications
Nonlesional focal epilepsies (nlFE) represent a heterogenous group of syndromes. They encompass self-limited focal epilepsies of childhood and youth,...
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A multicenter, matched case–control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany
BackgroundDepending on the underlying etiology and epilepsy type, the burden of disease for patients with seizures can vary significantly. This...
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Disruption of EEG resting state functional connectivity in patients with focal epilepsy
BackgroundEpilepsy is a network disease and EEG could be used to evaluate dynamic inter-regional connectivity. The aim of the current study is to...
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Multivariate analysis of seizure outcomes after resective surgery for focal epilepsy: a single-center study on 833 patients
The predictors of seizure outcomes after resective surgery for focal epilepsy, for an update on the features of good and poor outcomes, are...
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Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study
IntroductionDespite new anti-seizure medications (ASMs) being introduced into clinical practice, about one-third of people with epilepsy do not reach...
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Protocol of a prospective multicenter randomized controlled trial of robot-assisted stereotactic lesioning in the treatment of focal drug-resistant epilepsy
BackgroundThis protocol describes the design of a multicenter randomized controlled trial of robot-assisted stereotactic lesioning versus...
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Brivaracetam use in clinical practice: a Delphi consensus on its role as first add-on therapy in focal epilepsy and beyond
BackgroundAntiseizure medications remain the cornerstone of treatment for epilepsy, although a proportion of individuals with the condition will...
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High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial)
IntroductionThe standard treatment for patients with focal drug-resistant epilepsy (DRE) who are not eligible for open brain surgery is the...
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A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal-Onset Epilepsy
Background and objectivesEslicarbazepine acetate (ESL) is a third-generation anti-seizure medication for patients with focal-onset epilepsy. There...
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Navigated transcranial magnetic stimulation to measure motor evoked potentials in a child with hemispheric polymicrogyria and focal epilepsy
Malformations of cortical development such as polymicrogyria can cause medically refractory epilepsy. Epilepsy surgery (hemispherotomy) can be a good...
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What is the impact of a novel DEPDC5 variant on an infant with focal epilepsy: a case report
BackgroundVariants in the DEPDC5 have been proved to be main cause of not only various dominant familial focal epilepsies, but also sporadic focal...
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Neuropsychological performance in patients with focal drug-resistant epilepsy and different factors that affect their performance
BackgroundDrug-resistant epilepsy (DRE) accounts for nearly 30% of patients with epilepsy, which is associated with high incidence of cognitive...
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Map** analysis to predict SF-6D utilities from health outcomes in people with focal epilepsy
BackgroundFocal-onset seizures (FOS) are commonly experienced by people with epilepsy and have a significant impact on quality of life (QoL). This...
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Technical note: preliminary surgical experience with a new implantable epicranial stimulation device for chronic focal cortex stimulation in drug-resistant epilepsy
PurposeThis study is to report some preliminary surgical considerations and outcomes after the first implantations of a new and commercially...
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Self-limited focal epilepsies of childhood syndromes (SeLFEs)—an overview
Self-limited focal epilepsies of childhood syndromes (SeLFEs) comprise a group of disorders historically also widely known as “idiopathic focal...
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Managing delayed or missed pregabalin doses in patients with focal epilepsy: a Monte Carlo simulation study
BackgroundDelayed or missed doses are inevitable in epilepsy pharmacotherapy. The current remedial measures recommended by the United States Food and...
