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Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer
PurposeAnterior gradient 3 (AGR3) is associated with breast cancer progression, but its relationship with estrogen and tamoxifen resistance in breast...
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Analysis of serum reproductive hormones and ovarian genes in pubertal female goats
BackgroundAge at puberty is an important factor affecting goat fertility, with endocrine and genetic factors playing a crucial role in the onset of...
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Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational...
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Identification of hub genes to determine drug-disease correlation in breast carcinomas
The exact molecular mechanism underlying the heterogeneous drug response against breast carcinoma remains to be fully understood. It is urgently...
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Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer
BackgroundThe metastasis and aggressive nature of prostate cancer (PCa) has become a major malignancy related threat that concerns men’s health. The...
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Cell type-specific potential pathogenic genes and functional pathways in Alzheimer’s Disease
BackgroundAlzheimer's disease (AD) is a pervasive age-related and highly heritable neurodegenerative disorder but has no effective therapy. The...
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Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level
ObjectiveKeratoconus (KC) is a condition characterized by progressive corneal steepening and thinning. However, its pathophysiological mechanism...
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In silico analysis of differentially expressed-aberrantly methylated genes in breast cancer for prognostic and therapeutic targets
Breast cancer (BC) is the leading cause of death among women across the globe. Abnormal gene expression plays a crucial role in tumour progression,...
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Understanding polycystic ovary syndrome in light of associated key genes
BackgroundPolycystic ovary syndrome (PCOS) is an endocrinopathy affecting women of reproductive age group at a global level. According to many...
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Interactions dietary components with expression level of breast cancer-related genes
BackgroundDietary components can influence the effects of genetic background in breast cancer (BC). This review study aimed to investigate the effect...
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Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor
Hormone receptor-positive, HER2-negative advanced breast cancers exhibit high sensitivity to CDK4/6 inhibitors such as palbociclib. However, most...
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Integrative Analysis of Core Genes and Biological Process Involved in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disordered disease, affecting the function of the ovaries in women of...
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Identification of hub genes and diagnostic efficacy for triple-negative breast cancer through WGCNA and Mendelian randomization
ObjectiveTriple-negative breast cancer (TNBC) represents a particularly aggressive form of breast cancer with a poor prognosis due to a lack of...
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Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s disease
There is growing evidence of a shared pathogenesis between Alzheimer’s disease and depression. Therefore, we aimed to further investigate their...
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The prognostic genes model of breast cancer drug resistance based on single-cell sequencing analysis and transcriptome analysis
Breast cancer (BC) represents a multifaceted malignancy, with escalating incidence and mortality rates annually. Chemotherapy stands as an...
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Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes
Oncogenic metabolic reprogramming impacts the abundance of key metabolites that regulate signaling and epigenetics. Metabolic vulnerability in the...
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SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β
Silent mating type information regulation 2 homolog 1 (SIRT1) is a class III histone deacetylase (HDAC) that is NAD + dependent and essential for...
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Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells
The functions and molecular mechanisms of long noncoding RNA (lncRNA) in reproduction have been widely studied at present. However, lncRNA regulating...
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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer
Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk...
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Bioinformatically deciphering immune cell infiltration and signature genes in pelvic organ prolapse
Introduction and hypothesisThe study is aimed at bioinformatically deciphering immune cell infiltration, signature genes, and their correlations in...
