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TET2 Is Downregulated in Early Esophageal Squamous Cell Carcinoma and Promotes Esophageal Squamous Cell Malignant Behaviors
ObjectiveTo explore the expression of the ten eleven translocation (TET) 2 protein in early esophageal squamous cell carcinoma (EESCC), precancerous...
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Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma
BackgroundThe rate of metachronous recurrence after endoscopic submucosal dissection for early-stage esophageal squamous cell carcinoma and...
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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression
Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial cancer formation and progression, but what molecules and...
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FOXP3 expression in esophageal squamous cell carcinoma
ObjectiveInvestigating the impact of FOXP3 (transcription factor forkhead box P3) expression on the biological behavior of esophageal squamous cell...
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Chemo-immunotherapy in advanced esophageal squamous cell carcinoma: present and future
With the recent progress in scientific research, the combination of chemotherapy and PD-1 blockade has become the new standard-of-care first-line...
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Non-endoscopic Screening for Esophageal Squamous Cell Carcinoma: Recent Advances
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most common tumors in the gastrointestinal tract, and China has a high incidence...
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Concordance of assessments of four PD-L1 immunohistochemical assays in esophageal squamous cell carcinoma (ESCC)
ObjectiveGiven real-world limitations in programmed death-ligand 1 (PD-L1) testing, concordance studies between PD-L1 assays are needed. We undertook...
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Outcomes of definitive carbon-ion radiotherapy for cT1bN0M0 esophageal squamous cell carcinoma
BackgroundA recent phase I/II study determined the optimal dose of definitive carbon-ion radiotherapy (CIRT) for cT1bN0M0 esophageal cancer. This...
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Esophageal squamous cell carcinoma with pagetoid spread: a clinicopathologic study
Pagetoid spread in esophageal squamous epithelium associated with underlying esophageal adenocarcinoma (EAC) has been well studied. Case reports...
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GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest forms of human malignancy that currently lacks approved targeted therapeutics....
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Definitive chemoradiotherapy induces T-cell-inflamed tumor microenvironment in unresectable locally advanced esophageal squamous cell carcinoma
BackgroundChemoradiotherapy (CRT) modulates the tumor immune microenvironment of multiple cancer types, including esophageal cancer, which...
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RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation
Retinoic acid-inducible gene-I (RIG-I) is considered a key sensor for host recognition of RNA virus infections. Recent studies have shown that RIG-I...
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Precise pattern of lymphatic spread of esophageal squamous cell carcinoma: results of 1074 patients with N1 disease
PurposeThe route of lymphatic spread in esophageal cancer remains unclear. The present study aimed to determine the pattern of lymphatic metastasis...
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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the...
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Therapeutic Potential of Antibody Targeting Neuronal Pentraxin Receptor in Esophageal Squamous Cell Carcinoma
BackgroundEsophageal squamous cell carcinoma (ESCC) has a poor prognosis despite advances in multidisciplinary treatments and immune checkpoint...
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Grading criteria for venous invasion in thoracic esophageal squamous cell carcinoma
BackgroundVenous invasion (VI) is an adverse prognostic indicator in esophageal squamous cell carcinoma. However, grading criteria for venous...
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Non-acid reflux and esophageal dysmotility is associated with early esophageal squamous cell carcinoma
BackgroundStudies have demonstrated that non-acid reflux (NAR) is associated with esophageal squamous cell carcinoma (ESCC). Esophageal dysmotility...
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miR-139-5p mediates TGIF1 to regulate the TGFβ pathway and inhibit growth of esophageal squamous cell carcinoma cells
BackgroundEsophageal squamous cell carcinoma (ESCC) is the most prevalent histological subtype of esophageal cancer. miR-139-5p has been shown to...
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Predictive factors for esophageal stenosis in patients receiving prophylactic steroid therapy after endoscopic submucosal dissection for esophageal squamous cell carcinoma
BackgroundMethods to prevent esophageal stenosis (ES) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma...
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Neoadjuvant Chemotherapy or Adjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma
BackgroundChemotherapy and chemoradiation have become essential adjuncts to improve the survival of patients with resectable esophageal squamous cell...
