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Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study
IntroductionDespite new anti-seizure medications (ASMs) being introduced into clinical practice, about one-third of people with epilepsy do not reach...
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Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Background and ObjectiveMost second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a...
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Dose Adjustment of Concomitant Antiseizure Medications During Cenobamate Treatment: Expert Opinion Consensus Recommendations
IntroductionOur objective was to provide expert consensus recommendations to improve treatment tolerability through dose adjustments of concomitant...
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Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
BackgroundCenobamate is an antiseizure medication (ASM) approved in the US and Europe for the treatment of uncontrolled focal seizures.
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Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended...
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Adjunctive Cenobamate for Focal-Onset Seizures in Adults: A Systematic Review and Meta-Analysis
BackgroundCenobamate is a novel tetrazole-derived carbamate compound with a dual mechanism of action. This drug can enhance the inactivated state of...
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An Ex Vivo Evaluation of Cenobamate Administered via Enteral Tubes
BackgroundCenobamate is a new, Food and Drug Administration (FDA)-approved oral antiepileptic drug for treatment of focal seizures in adults. This...
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Cenobamate: First Approval
Cenobamate (XCOPRI ® ) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle...
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The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond
Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as...
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System
γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in...
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Antiseizure Drugs and Movement Disorders
The relationship between antiseizure drugs and movement disorders is complex and not adequately reviewed so far. Antiseizure drugs as a treatment for...
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Further advances in epilepsy
In 2017, one of us reviewed advances in epilepsy (Manford in J Neurol 264:1811–1824, 2017). The current paper brings that review up to date and gives...
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Distinguishing Benign Rashes From Severe Skin Reactions From Anti-Seizure Medications
Purpose of reviewThis review describes risk factors for severe skin reactions to antiseizure medications (ASMs), the usage of updated tests to...
