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The influence of iron on bone metabolism disorders
Iron is a necessary trace element in the human body, and it participates in many physiological processes. Disorders of iron metabolism can cause...
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Different doses of phosphorus, calcium, and vitamin D in premature infants and their effect on bone mineralization: systematic review and meta-analysis
PurposeThis systematic review and meta-analysis aims to assess the impact of different doses of Ca, P, and vitamin D on bone mineralization in...
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Bone Material Properties in Bone Diseases Affecting Children
Purpose of ReviewMetabolic and genetic bone disorders affect not only bone mass but often also the bone material, including degree of mineralization,...
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Genetic Evaluation for Monogenic Disorders of Low Bone Mass and Increased Bone Fragility: What Clinicians Need to Know
Purpose of ReviewThe purpose of this review is to outline the principles of clinical genetic testing and to provide practical guidance to clinicians...
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Craniosynostosis in primary metabolic bone disorders: a single-institution experience
PurposeThe incidence of metabolic bone diseases in pediatric neurosurgical patients is rare. We examined our institutional experience of metabolic...
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Liver fibrosis is associated with impaired bone mineralization and microstructure in obese individuals with non-alcoholic fatty liver disease
Background and purposeChronic liver diseases are associated with increased bone fracture risk, mostly in end-stage disease and cirrhosis; besides,...
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Role of Wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders
SummaryWnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone homeostasis. The therapeutic potential of...
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Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cells...
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Skeletal and extraskeletal disorders of biomineralization
The physiological process of biomineralization is complex and deviation from it leads to a variety of diseases. Progress in the past 10 years has...
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Contribution of bone turnover markers (BTMs) and vitamin D to bone health in Iranian elderly women
PurposeWhile only a few postmenopausal women exhibit biochemical signs of hypovitaminosis D, it has been shown that vitamin D insufficiency has...
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Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg
Purpose of ReviewRecently, there has been an increasing number of studies on the crosstalk between the bone and the bone marrow and how it pertains...
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OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Dysregulation of this process...
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Gut hormones and bone homeostasis: potential therapeutic implications
Bone resorption follows a circadian rhythm, with a marked reduction in circulating markers of resorption (such as carboxy-terminal telopeptide region...
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Mixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney disease
Renal osteodystrophy (ROD) starts early and progresses with further loss of kidney function in patients with chronic kidney disease (CKD). There are...
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Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects
PurposeBone diseases account for an enormous cost burden on health systems. Bone disorders are considered as age-dependent diseases. The aging of...
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Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce
BackgroundInfants with chronic kidney disease (CKD) form a vulnerable population who are highly prone to mineral and bone disorders (MBD) including...
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Crosstalk between muscle and bone
Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged...
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Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study
IntroductionVitamin D deficiency causes osteoporosis, bone mineralization disorders, and osteomalacia. Osteomalacia is diagnosed using blood...
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Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders
Phosphorus, predominantly in the form of inorganic phosphate PO 4 −3 , has many essential physiological functions. In the skeleton, phosphate and...
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Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
The results of many studies in recent years indicate a significant impact of pituitary function on bone health. The proper function of the pituitary...