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Fabrication and evaluation of smart pH/thermo dual-responsive injectable intratumoral in situ depot hydrogels for controlled 5-FU delivery
Background5-FU has multiple applications in various cancers but has limitations owing to its shorter half-life and rapid metabolism. In this study,...
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Awareness and practice of airway pressure release ventilation mode in acute respiratory distress syndrome patients among nurses in Saudi Arabia
BackgroundThis study aimed to assess the knowledge and current practice of using the airway pressure release ventilation (APRV) mode with acute...
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Optimizing vancomycin release from novel carbon fiber-reinforced polymer implants with small holes: periprosthetic joint infection treatment
Periprosthetic joint infection (PJI) is a catastrophic complication after total hip arthroplasty. A new drug-loaded carbon fiber-reinforced polymer...
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Clinical Characteristics and Outcome of Immediate-Release Versus SLOW-Release Carvedilol in Heart Failure Patient (SLOW-HF): a Prospective Randomized, Open-Label, Multicenter Study
PurposeCarvedilol demonstrated therapeutic benefits in patients with heart failure and reduced ejection fraction (HFrEF). However, it had a short...
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The Breakthrough of Large Language Models Release for Medical Applications: 1-Year Timeline and Perspectives
Within the domain of Natural Language Processing (NLP), Large Language Models (LLMs) represent sophisticated models engineered to comprehend,...
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Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a randomised controlled trial
BackgroundDistressing symptoms are common in advanced cancer. Medicinal cannabinoids are commonly prescribed for a variety of symptoms. There is...
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Interferon-gamma release assay for screening of tuberculosis infection in children
BackgroundInterferon-gamma release assay (IGRA) is the main tool for the diagnosis of latent tuberculosis (TB) infection (LTBI). However, the...
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Changes in biomechanics, strength, physical function, and daily steps after extended-release corticosteroid injections in knee osteoarthritis: a responder analysis
Introduction/ObjectiveTo determine changes in gait biomechanics, quadricep strength, physical function, and daily steps after an extended-release...
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Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia
IntroductionMortality is elevated after prison release and may be higher in people with HIV and opioid use disorder (OUD). Maintenance with opioid...
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Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts
PurposeVentricular arrhythmias (VAs) are a common cause of sudden death in acute myocardial infarction (MI), for which hypertension is a major risk...
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In vitro cytotoxicity and anti-cancer drug release behavior of methionine-coated magnetite nanoparticles as carriers
A novel and specific drug delivery for in vitro cancer targeted are developed successfully by a simple one-step method. A CoFe 2 O 4 @Methionine...
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Does early tethered cord release in occult spinal dysraphism improve urological outcomes? A systematic review
IntroductionOccult spinal dysraphism involves a wide range of congenital anomalies, e.g., lipoma, Lipomeningomyelocele, congenital dermal sinus, etc....
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Optimal analgesic regimen for total shoulder arthroplasty: a randomized controlled trial and network meta-analysis
ObjectiveClinical approaches to analgesia following total shoulder arthroplasty include liposomal bupivacaine, local infiltration analgesia,...
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Value of estrogen pretreatment in patients with diminished ovarian reserve and elevated FSH on a line antagonist regimen: a retrospective controlled study
BackgroundThe key to enhancing the efficacy of antagonistic regimens in pregnancy is to better synchronize follicular growth during cycles of...
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Evaluating the feasibility of prolonged-release buprenorphine formulations as an alternative to daily opioid agonist therapy regardless of prior treatment adherence: a pilot study
BackgroundEffective opioid agonist therapy (OAT) depends on good patient adherence. However, the daily, supervised administration of standard OAT...
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Improving Post-Release Care Engagement for People Living with HIV Involved in the Criminal Justice System: A Systematic Review
Given sub-optimal HIV care outcomes for people living with HIV (PLWH) post-release from incarceration, we systematically searched peer-reviewed...
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A prospective randomised controlled trial of mechanical axis with soft tissue release balancing vs functional alignment with bony resection balancing in total knee replacement—a study using Stryker Mako robotic arm-assisted technology
BackgroundImproving the functional outcome following total knee arthroplasty (TKA) by using different alignment techniques remains controversial. The...
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Pharmacokinetics and Pharmacodynamics of Esomeprazole/Sodium Bicarbonate Immediate-Release Capsules in Healthy Chinese Volunteers: A Cross-Over, Randomized Controlled Trial
IntroductionEsomeprazole delayed release tablets (ESO) are one of the most effective treatments for acid-related disorders. The purpose of this study...
