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A current review of spinal meningiomas: epidemiology, clinical presentation and management
PurposeTo provide an up-to-date review of the epidemiology, histopathology, molecular biology, and etiology of spinal meningiomas, as well as discuss...
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Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is...
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The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelium is a stratified epithelium composed of basal cells, one or more layers of intermediate cells, and an upper layer of differentiated...
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Metabolic guidance and stress in tumors modulate antigen-presenting cells
Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the capacity of APCs is found...
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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs...
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Neural cell state shifts and fate loss in ageing and age-related diseases
Most age-related neurodegenerative diseases remain incurable owing to an incomplete understanding of the disease mechanisms. Several environmental...
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Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4
Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer (PCa). The histone methyltransferase KMT2D, a frequently...
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Mechanosensing and Mechanosignal Transduction in Atherosclerosis
Purpose of ReviewThis review aims to summarize the latest findings on mechanosensing in atherosclerosis, elucidating the molecular mechanisms,...
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Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomas
AimsSkull base meningiomas represent approximately 25% of all meningiomas, nearly 20% of which are atypical or anaplastic. To date, effective medical...
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The role of RNA modification in urological cancers: mechanisms and clinical potential
RNA modification is a post-transcriptional level of regulation that is widely distributed in all types of RNAs, including mRNA, tRNA, rRNA, miRNA,...
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The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders
Excessive fat deposition in obese subjects promotes the occurrence of metabolic diseases, such as type 2 diabetes mellitus (T2DM), cardiovascular...
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Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation
ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function...
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Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -naïve patients: a multicenter retrospective analysis
BackgroundThe incidence of gastric neoplasms in Helicobacter pylori (Hp) -naïve patients has recently increased due to a remarkable decrease in the Hp ...
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The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic metabolic homeostasis. Additionally, adipose tissue is a...
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Transcriptional Regulation in the Control of Aging and Longevity
AbstractTranscription regulation is required for correct differential gene expression, which determines the development and function of all cells in...
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Current status of molecular diagnostic approaches using liquid biopsy
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers, and develo** an efficient and reliable approach for its...
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Emerging Roles of Extracellular Non-Coding RNAs in Vascular Diseases
Extracellular vesicles (EVs) are secreted by cells and carry diverse components, including proteins, lipids, nucleic acids, and metabolites. EVs...
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RNA N6-methyladenosine modification in regulating cancer stem cells and tumor immune microenvironment and its implication for cancer therapy
Therapy resistance is a well-known phenomenon in cancer treatment. It can be intrinsic or acquired, accountable for frequent tumor relapse and death...
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Translational research in Hirschprung’s disease at the National Children’s Research Centre in Dublin
Hirschsprung’s disease (HD) is a congenital condition characterised by aganglionosis in the distal bowel. Over the years, at the National Children’s...
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Biased expression of mutant alleles in cancer-related genes in esophageal squamous cell carcinoma
BackgroundRecent progress of large-scale international studies has provided comprehensive catalogs of somatic mutations in cancers. Additionally, it...
