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Association of aromatase and estrogen receptor gene polymorphisms with hip fractures
SummaryTwo polymorphisms of the aromatase and estrogen receptor genes appeared to interact to influence the risk of hip fractures in women.
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Differential Gene Expression Profiling in HELLP Syndrome Placentas
The aim of this study was to identify differentially expressed genes by suppression subtractive hybridization (SSH) in HELLP placentas. Two cDNA...
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Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance
Approximately 30% of patients with estrogen receptor (ER) positive breast cancers exhibit de novo or intrinsic resistance to endocrine therapies. The...
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CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women
Object:To examine the relationship between genetic polymorphisms of the CYP19A1 gene and obesity-related phenotypes, body mass index (BMI) and...
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A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
Due to the established association between estrogen levels and breast cancer risk, polymorphic variation in genes regulating estrogen levels is...
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Recognizing rare disorders: aromatase deficiency
Aromatase deficiency is rare in humans. Affected individuals cannot synthesize endogenous estrogens. Aromatase is the enzyme that catalyzes...
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COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells
We previously showed that COUP-TFI interacts with the Estrogen Receptor alpha (ERα) to recruit Extracellular signal Regulated Kinases (ERKs) in an...
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Identification of new participants in the rainbow trout (Oncorhynchus mykiss) oocyte maturation and ovulation processes using cDNA microarrays
BackgroundThe hormonal control of oocyte maturation and ovulation as well as the molecular mechanisms of nuclear maturation have been thoroughly...
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Vertebral body integrity: a review of various anatomical factors involved in the lumbar region
SummaryThe body of the vertebra can be affected in the majority of the conditions involving the lumbar spine. Multiple references, both books and...
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The genetics of the polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a very common endocrine disorder that has a strong genetic component and is characterized by polycystic ovaries,...
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Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis
Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid...
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A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches
BackgroundNumerous studies point to a positive relationship between elevated levels of estrogens and increased risk of breast. Androgens are...
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Cytochrome P450 Oxidoreductase Deficiency in Three Patients Initially Regarded as Having 21-Hydroxylase Deficiency and/or Aromatase Deficiency: Diagnostic Value of Urine Steroid Hormone Analysis
In this study, we report on three Japanese patients with cytochrome P450 oxidoreductase (POR) deficiency (PORD). Case one was a 46,XY patient who was...
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Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression
Chemotherapy with the alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitrosourea) is the most commonly used chemotherapeutic agent for gliomas....
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Effects of drug treatment for malignancy on skeletal health of cancer survivors
Cancer treatment has advanced and survivorship is increasing. As such, a new skeletal complication of malignancy, cancer treatment-induced bone loss,...