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From the periphery to the brain: Wiring the olfactory system
The olfactory system represents a perfect model to study the interactions between the central and peripheral nervous systems in order to establish a...
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A peculiar constellation of tau pathology defines a subset of dementia in the elderly
Sporadic tauopathies are characterized by differential cellular and topographical predominance of phospho-tau immunoreactivity and biochemical...
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Neuropathological background of phenotypical variability in frontotemporal dementia
Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a heterogeneous group of pathological disorders. With recent discoveries,...
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Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity
Tau is the pathological protein in several neurodegenerative disorders classified as frontotemporal lobar degeneration (FTLD), including corticobasal...
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Abnormal tau phosphorylation in primary progressive multiple sclerosis
Although neurodegeneration is the pathological substrate of progression in multiple sclerosis (MS), the underlying mechanisms remain unresolved....
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Brain biopsy in dementia: clinical indications and diagnostic approach
Brain biopsy may be performed to make a definitive diagnosis in patients with rapidly progressive dementia. To assess the value of this procedure, we...
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Biological fluid biomarkers in neurodegenerative parkinsonism
Patients with parkinsonian symptoms can present either to primary care physicians or to neurologists. In both contexts, differential diagnosis is...
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Synaptic organization of the olfactory bulb based on chemical coding of neurons
Olfaction is one of the chemical senses in both vertebrate and invertebrate animals essential for a variety of social behaviors. Recent molecular...
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Molekulare Neuropathologie der Nicht-Alzheimer-Demenzen
The increasing life expectancy will cause an increasing share for neurodegenerative and dementing illnesses in the total cost for health care. New...
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Argyrophilic thorny astrocyte clusters in association with Alzheimer’s disease pathology in possible primary progressive aphasia
Although most cases of primary progressive aphasia (PPA) have one of the varieties of frontotemporal lobar degeneration (FTLD) as their pathological...
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Progressive supranuclear palsy (PSP): a quantitative study of the pathological changes in cortical and subcortical regions of eight cases
In eight cases of progressive supranuclear palsy (PSP), neurofibrillary tangles (NFT) were numerous in the substantia nigra (SN), red nucleus (RN),...
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MAPT S305I mutation: implications for argyrophilic grain disease
Frontotemporal lobar degeneration (FTLD) with mutations in the tau gene (MAPT) causes familial frontotemporal dementia with tau pathology. Many of...
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Hippocampal sclerosis dementia: a reappraisal
Hippocampal sclerosis (HpScl) is characterized by neuronal loss and gliosis in CA1 and subiculum of the hippocampus, and may be one contributing...
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Phosphorylation and cleavage of tau in non-AD tauopathies
The tau protein, well known as the primary component of neurofibrillary tangles, also comprises the Pick bodies found in Pick’s disease (PiD) and the...
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The novel Tau mutation G335S: clinical, neuropathological and molecular characterization
Mutations in Tau cause the inherited neurodegenerative disease, frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). Known...
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Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer’s disease and tauopathies to granulovacuolar degeneration bodies
Protein misfolding is a distinguishing feature of a number of neurodegenerative diseases. Accumulation of misfolded protein often results in cellular...
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The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
Immunohistochemical detection of protein components of pathological inclusions is widely used for neuropathological diagnosis of neurodegenerative...
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Pathologic changes of progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy
Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA) are manifested as atypical parkinsonism....