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Monitoring synaptic pathology in Alzheimer’s disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives
Alzheimer’s disease (AD) is currently constrained by limited clinical treatment options. The initial pathophysiological event, which can be traced...
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Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Seizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease....
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Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers
PurposeSynaptic vesicle protein 2A (SV2A) serves as a biomarker of synaptic density and positron emission tomography (PET) imaging of SV2A could...
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[18F]SynVesT-1 and [18F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II
PurposeMRI-negative children with focal cortical dysplasia type II (FCD II) are one of the most challenging cases in surgical epilepsy management. We...
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Brivaracetam – eine gute Alternative zur Behandlung von Muskelkrämpfen
BackgroundMuscle cramps are suddenly occurring involuntary, mostly painful contractions of a single muscle, rarely of a muscle group. They can be...
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Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue
PurposeA [ 11 C]UCB-J blocking study was performed in healthy volunteers to validate simplified, non-invasive measures for quantifying presynaptic...
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
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Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein...
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Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy
IntroductionSelf-limited infantile epilepsy (SeLIE) is a benign epilepsy. Previous studies have shown that monotherapy with most antiseizure...
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11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies
ObjectiveDementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is...
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Therapeutic options for patients with status epilepticus in old age—English version
Status epilepticus (SE) is a serious acute condition that requires early and targeted treatment. Especially refractory SE (RSE) as well as...
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Synaptic plasticity and mental health: methods, challenges and opportunities
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that allows neurons to communicate and change their connections...
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Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder
Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding...
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Preclinical In Vitro and In Vivo Characterization of Synaptic Vesicle 2A–Targeting Compounds Amenable to F-18 Labeling as Potential PET Radioligands for Imaging of Synapse Integrity
PurposeCurrent synaptic vesicle 2A (SV2A) positron emission tomography (PET) imaging agents include the nanomolar affinity probes [ 11 C]UCB-J and [ 18 F...
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Therapeutische Optionen für Patienten mit Status epilepticus im höheren Lebensalter
Status epilepticus (SE) is a serious acute condition that requires early and targeted treatment. Especially refractory SE (RSE) as well as...
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Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities
Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the...
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