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Stroke-like lesions confined to the cerebellum in MELAS and a possible association with neuronal hyperexcitability

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References

  1. Oyama M, Iizuka T, Nakahara J, Izawa Y (2020) Neuroimaging pattern and pathophysiology of cerebellar stroke-like lesions in MELAS with m.3243A>G mutation: a case report. BMC Neurol 20(1):167

    Article  CAS  Google Scholar 

  2. Ng YS, Lax NA, Blain AP, Erskine D et al (2022) Forecasting stroke-like episodes and outcomes in mitochondrial disease. Brain 145:542–554

    Article  Google Scholar 

  3. Muramatsu D, Yamaguchi H, Iwasa K, Yamada M (2019) Cerebellar hyperintensity lesions on diffusion-weighted MRI in MELAS. Intern Med (Tokyo, Japan) 58(12):1797–1798

    Article  Google Scholar 

  4. Betts J, Jaros E, Perry RH, Schaefer AM, Taylor RW, Abdel-All Z et al (2006) Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement. Neuropathol Appl Neurobiol 32(4):359–373

    Article  CAS  Google Scholar 

  5. Love S, Perry A, Ironside J, Budka H. Greenfield’s Neuropathology. 9th Edn, p 542

  6. Iizuka T, Sakai F, Kan S, Suzuki N (2003) Slowly progressive spread of the stroke-like lesions in MELAS. Neurology 61(9):1238–1244

    Article  Google Scholar 

  7. Iizuka T, Sakai F (2005) Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. Curr Neurovasc Res 2(1):29–45

    Article  CAS  Google Scholar 

  8. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA (2010) Glial and neuronal control of brain blood flow. Nature 468(7321):232–243

    Article  CAS  Google Scholar 

  9. Bajjalieh SM, Frantz GD, Weimann JM, McConnell SK, Scheller RH (1994) Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci 14(9):5223–5235

    Article  CAS  Google Scholar 

  10. Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D et al (2018) Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. J Cereb Blood Flow Metab 38(11):2041–2052

    Article  CAS  Google Scholar 

  11. Stockburger C, Miano D, Baeumlisberger M, Pallas T, Arrey TN, Karas M et al (2016) A Mitochondrial role of SV2a protein in aging and Alzheimer’s disease: studies with levetiracetam. J Alzheimer’s Dis JAD 50(1):201–215

    Article  CAS  Google Scholar 

  12. Finsterer J, Scorza FA (2017) Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival. Epilepsy Res 136:5–11

    Article  CAS  Google Scholar 

  13. Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Katayama K et al (2007) MELAS and L-arginine therapy. Mitochondrion 7(1–2):133–139

    Article  CAS  Google Scholar 

  14. Hirata K, Akita Y, Povalko N, Nishioka J, Yatsuga S, Matsuishi T et al (2008) Effect of L-arginine on synaptosomal mitochondrial function. Brain Develop 30(4):238–245

    Article  Google Scholar 

  15. Frederiksen AL, Andersen PH, Kyvik KO, Jeppesen TD, Vissing J, Schwartz M (2006) Tissue specific distribution of the 3243A->G mtDNA mutation. J Med Genet 43(8):671–677

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to acknowledge the Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan; Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan for technical support of the exome sequencing. We thank Bronwen Gardner, PhD, from Edanz (https://jp.edanz.com/ac) for providing English editing assistance for a draft of this manuscript.

Funding

No funding was received to assist with the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Cerebrovascular Medicine and Neurology, Steel Memorial Yawata Hospital, Kitakyushu, Japan

    Taisuke Kitamura, Mio Yokoi, Takako Maruyama, Masato Osaki & Shuji Arakawa

  2. Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan

    Masahiro Shijo

  3. Diabetes Center, Steel Memorial Yawata Hospital, Kitakyushu, Japan

    Udai Nakamura

Authors
  1. Taisuke Kitamura
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  2. Masahiro Shijo
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  3. Mio Yokoi
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  4. Takako Maruyama
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  5. Masato Osaki
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  6. Udai Nakamura
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  7. Shuji Arakawa
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Contributions

TK: writing—original draft, resources; MS: writing—review and editing, supervision; MY: writing-review and editing; TM: writing—review and editing; MO: writing—review and editing; UN: resources; SA: supervision.

Corresponding author

Correspondence to Taisuke Kitamura.

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None.

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Informed consent was obtained from the patient for the publication of this case report.

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Kitamura, T., Shijo, M., Yokoi, M. et al. Stroke-like lesions confined to the cerebellum in MELAS and a possible association with neuronal hyperexcitability. J Neurol 270, 565–568 (2023). https://doi.org/10.1007/s00415-022-11397-0

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  • DOI: https://doi.org/10.1007/s00415-022-11397-0

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