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Ultrasound and MR imaging of peripheral nerve tumors: the state of the art
Peripheral nerve sheath tumors are a heterogeneous subgroup of soft tissue tumors that either arise from a peripheral nerve or show nerve sheath...
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Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor
The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is dismal, with surgical resection being the only definitive salvage...
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Unusual split green-orange signals in USP6 fluorescence in situ hybridization in a malignant peripheral nerve sheath tumor with a novel NF1-SCIMP fusion: a potential diagnostic pitfall
Deletion of the neurofibromatosis 1 ( NF1 ) gene is common, but NF1 rearrangement or fusion has rarely been reported in peripheral nerve sheath tumors....
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Rare malignant melanotic nerve sheath tumors of the upper limb nerves: utility of high-frequency ultrasonography in preoperative imaging
Melanotic nerve sheath tumor (MNST) is a rare variant of schwannoma. Here, we report an unusual case of multiple MNST lesions located in the upper...
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Diagnostic value of 18F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients
PurposeDetecting malignant peripheral nerve sheath tumors (MPNSTs) remains difficult. 18 F-FDG PET-CT has been shown helpful, but ideal threshold...
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MRI features of benign peripheral nerve sheath tumors: how do sporadic and syndromic tumors differ?
ObjectivesTo compare MRI features of sporadic and neurofibromatosis syndrome–related localized schwannomas and neurofibromas.
Methods ...
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Correlation between imaging and histology in benign solitary retroperitoneal nerve sheath tumors: a pictorial review
BackgroundBenign nerve sheath tumors presenting as solitary retroperitoneal masses (RBNSTs) pose a complex diagnostic challenge for multidisciplinary...
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Peripheral nerve sheath tumor: differentiation of malignant from benign tumors with conventional and diffusion-weighted MRI
ObjectivesTo evaluate potential of conventional MRI and diffusion-weighted imaging (DWI) for differentiating malignant from benign peripheral nerve...
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Systemic Options for Malignant Peripheral Nerve Sheath Tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are rare mesenchymal neoplasms that represent a profound therapeutic challenge due to their high...
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Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity
ObjectiveBenign nerve sheath tumors (BNSTs) present diagnostic challenges due to their heterogeneous nature. This study aimed to determine the...
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Unusual Presentation of Malignant Peripheral Nerve Sheath Tumour of Mandible as a Colossal Tumour After Neoadjuvant Chemotherapy
The uniqueness of this case is the presentation of malignant peripheral nerve sheath tumors arising from the mandible as a colossal tumor of size of...
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Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that frequently harbor genetic alterations in polycomb repressor complex 2...
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Incidence and prognosis of distant metastasis in malignant peripheral nerve sheath tumors
BackgroundMalignant peripheral nerve sheath tumors (MPNSTs) are a type of soft tissue sarcomas (STS) with recurrence and metastatic potential. We...
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Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, including the present case,...
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Synovial sarcoma of the tibial nerve - case report of a rare tumor in a rare location requiring early diagnosis
BackgroundWe present the case of a patient with a rare synovial sarcoma (SS) of the tibial nerve. So far, only 4 cases of patients with SS...
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Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics
BackgroundA definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1...
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Percutaneous image-guided biopsy in malignant peripheral nerve sheath tumors
BackgroundThe decision to biopsy a peripheral nerve tumor is largely based on its presumed behavior and prognosis, determined by patient history,...
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