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A Constrained Interval-Valued Linear Regression Model: A New Heteroscedasticity Estimation Method
Linear regression models for interval-valued data have been widely studied. Most literatures are to split an interval into two real numbers, i.e.,...
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Statistical Inference for Multicomponent System Stress-Strength Model with Bounded Strengths
In this paper, the statistical inference for system stress-strength reliability with bounded strength is discussed. When the stress and strength...
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Symbolic Data Analysis
Big data nowadays are available in the Internet, in businesses, and in government databases, among others, all the while challenging the capacity of...
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Composite Quantile Estimation for Kink Model with Longitudinal Data
Kink model is developed to analyze the data where the regression function is two-stage piecewise linear with respect to the threshold covariate but...
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Computational Prediction of Cardiac Electropharmacology - How Much Does the Model Matter?
Animal data describing drug interactions in cardiac tissue are abundant, however, nuanced inter-species differences hamper the use of these data to...
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A Time-Series Approach to Assess Physiological and Biomechanical Regulatory Mechanisms
In various areas of Medicine there is interest to incorporate information on homeostasis and regulation to increase the predictive power of...
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Examples of Big Data
BIG DATA comes in many flavors and dimensions. It may take the form of medical data on a patient where several characteristics are measured, or it...
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A Computational Study of Blood Flow Dynamics in the Pulmonary Arteries
In this work we study the blood dynamics in the pulmonary arteries by means of a 3D-0D geometric multiscale approach, where a detailed 3D model for...
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Periodic functions
We live in a periodic world. Not only are there the obvious periodicities of the day, the lunar month, and the year, which affect our circadian...
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Recent Computational Investigations of Leaflet Flutter in Thinner Biological Heart Valve Tissues
Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations....
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Control, Sensitivity and Identification of a Cardiovascular-Respiratory System Model
This work examines a cardiovascular-respiratory system model capable of describing its dynamic response to a constant workload. The heart rate and...
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Analysis of Cardiac Contraction Patterns
Heart failure is defined as a syndrome characterized by a remodeling in the cardiac muscle structure that diminishes the strength and synchrony of...
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Nonlinear dynamics of two-dimensional cardiac action potential duration map** model with memory
The aim of this work is the analysis of the nonlinear dynamics of two-dimensional map** model of cardiac action potential duration (2D-map APD)...
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Recognition of a Quasi-Periodic Sequence Containing an Unknown Number of Nonlinearly Extended Reference Subsequences
AbstractA previously unstudied optimization problem induced by noise-proof recognition of a quasi-periodic sequence, namely, by the recognition of a...
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Modelling and Simulation for Preclinical Cardiac Safety Assessment of Drugs with Human iPSC-Derived Cardiomyocytes
As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac arrhythmias by impeding the heart’s electrical and...
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Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence–uniqueness, finite element computation and application to multiple ischemic disease
In this study, the cardiac electro-mechanical model in a deforming domain is taken with the addition of mechanical feedback and stretch-activated...
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A High Performance Computing Framework for Finite Element Simulation of Blood Flow in the Left Ventricle of the Human Heart
We present a high performance computing framework for finite element simulation of blood flow in the left ventricle of the human heart. The...
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Reduced Models of Cardiomyocytes Excitability: Comparing Karma and FitzHugh–Nagumo
Since Noble adapted in 1962 the model of Hodgkin and Huxley to fit Purkinje fibres, the refinement of models for cardiomyocytes has continued. Most...
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Projection-based Consistent Test for Linear Regression Model with Missing Response and Covariates
In recent years, there has been a large amount of literature on missing data. Most of them focus on situations where there is only missingness in...