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Impedimetric monitoring of microRNA-200c-3p using hydroxyapatite nanoparticles modified pencil graphite electrodes
It is important to monitor miRNA-200c-3p as it can potentially serve as an important biomarker for respiratory diseases including COVID-19 and...
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MicroRNA-208a silencing against myocardial ischemia/reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes
MicroRNA-208a (miR-208a) plays critical roles in the severe fibrosis and heart failure post myocardial ischemia/reperfusion (IR) injury. MiR-208a...
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RNA-based nanomedicines and their clinical applications
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or...
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The Evolution and Emergence of 2D Nanomaterial Based Electro-Chemical and Fluorescent Biosensors
The precise functionalization of nanostructures and recent advancement in the same field have created new opportunities for biosensors that may be...
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Regulating Nanozymes for Bioanalysis
Nanozymes with enzyme-like activity can perform catalytic reactions like enzymes. Nanozymes have been extensively used in biosensing, biomedicine,...
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Endogenous dual miRNA-triggered dynamic assembly of DNA nanostructures for in-situ dual siRNA delivery
A theranostic strategy of multiple microRNA (miRNA)-triggered in-situ delivery of small interfering RNA (siRNA) can effectively improve the precise...
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Nanomedicine-based treatment: An emerging therapeutical strategy for pulmonary hypertension
Pulmonary hypertension (PH) can cause breathing difficulty, a rapid decline of exercise capacity, heart failure, and eventually death of the...
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Locked nucleic acids based DNA circuits with ultra-low leakage
DNA circuits based on toehold-mediated DNA strand displacement reaction are powerful tools owing to their programmability and predictability....
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Preparation, applications, and challenges of functional DNA nanomaterials
As a carrier of genetic information, DNA is a versatile module for fabricating nanostructures and nanodevices. Functional molecules could be...
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Modified screen-printed electrochemical biosensor design compatible with mobile phones for detection of miR-141 used to pancreatic cancer biomarker
MicroRNAs (miRNAs) are emerging materials as ideal biomarkers for noninvasive cancer detection in the early phase. In this article, a simple and...
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Principles of amino-acid–ribonucleotide interaction revealed by binding affinities between homogeneous oligopeptides and single-stranded RNA molecules
We have determined the binding strengths between ribonucleotides of adenine (A), guanine (G), uracil (U), and cytosine (C) in homogeneous...
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Recent Advances in Ultrasensitive miRNA Biomarkers Detection
Recently, microRNAs gain a great interest in the bio-molecular field due to their fundamental role in clinical diagnostics. In this chapter, we...
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Mesenchymal stem cell-derived exosomes: versatile nanomaterials for skin wound treatment
Accumulating studies reveal that mesenchymal stem cells (MSCs) promote skin wound healing mainly through the paracrine effects. Exosomes, one of the...
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Time-resolved luminescent nanoprobes based on lanthanide nucleotide self-assemblies for alkaline phosphatase detection
Currently, enzyme-responsive nanomaterials have shown great promise in prognosis or diagnosis of disease biomarker. However, the great obstacle for...
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Enhanced population of excited single state strategy: irradiation and ultrasound dual-response and host tumor-driven nano-sensitizers construction in triple synergistic therapy
Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen...
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Intranasal administration nanosystems for brain-targeted drug delivery
The existence of the blood-brain barrier (BBB) restricts the entry of drugs from the circulation into the central nervous system (CNS), which...
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Screen-Printed Electrochemical Sensors and Biosensors for Detection of Biomarkers
In this chapter, the use of miniaturized 2D-printed electrochemical devices for the detection of biomarkers is explored. This section reports the...
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EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment
Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates, which are largely attributed to the...
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Native and engineered exosomes for inflammatory disease
Exosomes are extracellular vesicles which carry specific molecular information from donor cells and act as an intercellular communication vehicle,...
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Plasmonic nanostructures acting as a light-driven O2-sensitive nitroreductase mimic for enhanced photochemical oxidation of para-aminothiophenol
Nanozymes, as a novel form of enzyme mimics, have garnered considerable interest. Despite overcoming the main disadvantages of their natural analogs,...
