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Phase Separation in Living Cells Benefits and Risks
This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells...
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Analysis of Phase Separation of EARLY FLOWERING 3
Phase separation is an important mechanism for regulating various cellular functions. The EARLY FLOWERING 3 (ELF3) protein, an essential element of...
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VAMP2 regulates phase separation of α-synuclein
α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such as Parkinson’s disease and Lewy body dementia, undergoes protein...
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MYC phase separation selectively modulates the transcriptome
Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For...
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Phase separation in fungi
Phase separation, in which macromolecules partition into a concentrated phase that is immiscible with a dilute phase, is involved with fundamental...
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Phase Separation of Phytochrome B in HEK293T Cells
In this method, we employed HEK293T cells to express the plant photoreceptor phytochrome B (phyB). Through the application of various treatments such...
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Phase separation of RNF214 promotes the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in...
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Crosstalk between protein post-translational modifications and phase separation
The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current...
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Phase separation as a possible mechanism for dosage sensitivity
BackgroundDeletion of haploinsufficient genes or duplication of triplosensitive ones results in phenotypic effects in a concentration-dependent...
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Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets"...
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A phase separation-fortified bi-specific adaptor for conditional tumor killing
A common approach in therapeutic protein development involves employing synthetic ligands with multivalency, enabling sophisticated control of signal...
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Emerging Role of Phase Separation in COVID-19
Viral infections have particularly been attracting attention after the spread of the novel coronavirus (SARS-CoV-2) in 2019. Viruses have a simple...
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Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
BackgroundBromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in...
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Oxidative Stress Induced by Arsenite is Involved in YTHDF2 Phase Separation
YTH N 6 -methyladenosine RNA binding protein 2 (YTHDF2) undergoes phase separation in response to the stimulation of high concentration of arsenite,...
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Magnetic phase separation in microgravity
The absence of strong buoyancy forces severely complicates the management of multiphase flows in microgravity. Different types of space systems,...
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Phase Separation of Purified Human LSM4 Protein
AbstractLiquid–liquid phase separation of proteins occur in a number of biological processes, such as regulation of transcription, processing, and...
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APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation
The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin...
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Non-canonical MLL1 activity regulates centromeric phase separation and genome stability
Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent mutations in chromatin regulators, including the MLL/KMT2...
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Liquid-liquid phase separation in DNA double-strand breaks repair
DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs...
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Fluorescence Correlation Spectroscopy and Phase Separation
A quantitative understanding of the forces controlling the assembly and functioning of biomolecular condensates requires the identification of phase...