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Gapr for large-scale collaborative single-neuron reconstruction
Whole-brain analysis of single-neuron morphology is crucial for unraveling the complex structure of the brain. However, large-scale neuron...
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Local shape descriptors for neuron segmentation
We present an auxiliary learning task for the problem of neuron segmentation in electron microscopy volumes. The auxiliary task consists of the...
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A robust approach to 3D neuron shape representation for quantification and classification
We consider the problem of finding an accurate representation of neuron shapes, extracting sub-cellular features, and classifying neurons based on...
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Wie ein einzelnes Neuron das Überleben eines Fadenwurmes sichert
Sleep is a vital behavioral and physiological state. It is controlled by conserved genes and neuronal circuit mechanisms. In the round worm Caenorhabdi...
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NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis
Cell fate and proliferation ability can be transformed through reprogramming technology. Reprogramming glioblastoma cells into neuron-like cells...
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Recordings in an integrating central neuron reveal the mode of action of isoeugenol
Although isoeugenol is one of the most widely used anesthetics in fish, its actual mode of action and thus its applicability for particular...
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From pixels to connections: exploring in vitro neuron reconstruction software for network graph generation
Digital reconstruction has been instrumental in deciphering how in vitro neuron architecture shapes information flow. Emerging approaches reconstruct...
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Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell
Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an...
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Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic...
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Hidden Markov modeling for maximum probability neuron reconstruction
Recent advances in brain clearing and imaging have made it possible to image entire mammalian brains at sub-micron resolution. These images offer the...
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Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is a complicated neurodegenerative disease. Neuron-glial cell interactions are an important but not fully...
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Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction
The examination of post-mortem brain tissue suggests synaptic loss as a central pathological hallmark of schizophrenia spectrum (SCZ), which is...
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Reprogramming cultured human fungiform (HBO) taste cells into neuron-like cells through in vitro induction
Human taste cells are a heterogeneous population of specialized epithelial cells that are constantly generated from progenitor taste cells. Type I...
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Neuron numbers link innovativeness with both absolute and relative brain size in birds
A longstanding issue in biology is whether the intelligence of animals can be predicted by absolute or relative brain size. However, progress has...
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Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury
BackgroundSpinal cord injury (SCI) is an intractable neurological disease in which functions cannot be permanently restored due to nerve damage. Stem...
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Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS
The fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs)...
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Modelling Cross Talk in the Spatiotemporal System Dynamics of Calcium, IP3 and Nitric Oxide in Neuron Cells
The bioenergetic system of calcium ([Ca 2+ ]), inositol 1, 4, 5-trisphophate (IP 3 ) and nitric oxide (NO) regulate the diverse mechanisms in neurons....
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Altered glia-neuron communication in Alzheimer’s Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq
BackgroundAlzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and...
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Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
BackgroundThe detailed transcriptomic profiles during human serotonin neuron (SN) differentiation remain elusive. The establishment of a reporter...
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Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive decline. These impairments correlate with early alterations in...
