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MiREx: mRNA levels prediction from gene sequence and miRNA target knowledge
Messenger RNA (mRNA) has an essential role in the protein production process. Predicting mRNA expression levels accurately is crucial for...
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MiRNA–Gene Activity Interaction Networks (miGAIN): Integrated Joint Models of miRNA–Gene Targeting and Disturbance in Signaling Pathways
Omics data are now inexpensive to collect in vast quantities, across a wide variety of not only multiple data platform, but also distinct functional...
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A preliminary study of the miRNA restitution effect on CNV-induced miRNA downregulation in CAKUT
BackgroundThe majority of CAKUT-associated CNVs overlap at least one miRNA gene, thus affecting the cellular levels of the corresponding miRNA. We...
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Almond miRNA Expression and Horticultural Implications
From the past, till now various improved almond cultivars with desired traits have been introduced through breeding programs based on classical and...
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CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
BackgroundCalcific aortic valve disease (CAVD) is a common valve disease with an increasing incidence, but no effective drugs as of yet. With the...
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Endogenous miRNA Sponges
MicroRNAs (miRNAs) are a class of noncoding RNAs of 17–22 nucleotides in length with a critical function in posttranscriptional gene regulation....
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miRNA Biogenesis and Regulation of Diseases: An Updated Overview
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to the target mRNAs. Since it...
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Determining miRNA Expression Patterns in Xenopus
Whole-mount in situ hybridization (WISH) is a technique that enables temporal and spatial visualization of RNA molecules in an embryo or whole tissue...
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Serum miRNA-21, miRNA-146a and plasma cell free DNA as novel biomarkers for assessing systemic lupus erythematosus activity
BackgroundMicroRNA and cell-free DNA have shown significant correlations with several autoimmune disorders including systemic lupus erythematosus...
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Gene Silencing Using Artificial miRNA in Sugarcane
One of the most common ways to study gene function is to analyze loss-of-function mutants. In polyploid species, although gene redundancy presents...
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Identification of Functionally Significant Polymorphic Variants in miRNA Genes in Carotid Atherosclerosis
miRNAs are vital molecules of gene expression. They are involved in the pathogenesis of various common diseases, including atherosclerosis, its risk...
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Evaluation of miRNA Expression in 3D In Vitro Scaffold-Based Cancer Models
Accumulating experimental evidence suggests that 3D in vitro cancer models strengthen our understanding of vital processes in the tumor...
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Degradome sequencing reveals an integrative miRNA-mediated gene interaction network regulating rice seed vigor
BackgroundIt is well known that seed vigor is essential for agricultural production and rice ( Oryza sativa L.) is one of the most important crops in...
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The emerging roles of miRNA-mediated autophagy in ovarian cancer
Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early...
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An Efficient CRISPR-Cas9 Method to Knock Out MiRNA Expression in Xenopus Tropicalis
In recent years CRISPR-Cas9 knockouts (KO) have become increasingly utilized to study gene function. MicroRNAs (miRNAs) are short noncoding RNAs,...
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Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering
Posttranscriptional silencing by microRNAs (miRNAs) is a critical constituent of eukaryotic gene regulation. miRNAs are short (~22 nt) noncoding RNAs...
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Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors
AbstractLung cancer is one of the cancer types with the highest mortality worldwide. The most frequently mutated genes known to be clinically...
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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miRNA as biomarker in lung cancer
Lung cancer has a high prevalence and mortality due to its late diagnosis and limited treatment, so it is essential to find biomarkers that allow a...
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Gene Reporter Assays to Study miRNA Function
This chapter describes one of the most reliable quantitative assays to test the silencing of a possible target gene by a specific miRNA using a...