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Mechanosensitive Channels: History, Diversity, and Mechanisms
Abstract —Mechanical forces are inseparable from most cellular functions. Cell division, contraction, and adhesion generate intrinsic forces in the...
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Deciphering the role of mechanosensitive channels in plant root biology: perception, signaling, and adaptive responses
Main conclusionMechanosensitive channels are integral membrane proteins that rapidly translate extrinsic or intrinsic mechanical tensions into...
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Mechanosensitive aquaporins
Cellular systems must deal with mechanical forces to satisfy their physiological functions. In this context, proteins with mechanosensitive...
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Analysis of Possible Mechanisms of Endometrial Stem Cell Migration Suppression by Selective Chemical Activation of Piezo1 Mechanosensitive Channels
AbstractWe investigated the possible molecular mechanisms that could mediate the suppression of cell motility of human endometrial mesenchymal stem...
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Simulated Microgravity Changes the Number of Mechanically Gated and Mechanosensitive Ion Channels Genes Transcripts in Rat Ventricular Cardiomyocytes
AbstractThe mechanoelectrical feedback in the heart is based on the work of mechanically gated (MGCs) and mechanosensitive (MSCs) channels. Since...
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Origin, evolution and diversification of plant mechanosensitive channel of small conductance-like (MSL) proteins
Mechanosensitive (MS) ion channels provide efficient molecular mechanism for transducing mechanical forces into intracellular ion fluxes in all...
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Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids
Enterovirus A71 causes severe disease upon systemic infection, sometimes leading to life-threatening neurological dysfunction. However, in most cases...
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The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
Mechanosensitive ion channels are widely distributed in the heart, lung, bladder and other tissues, and plays an important role in exercise-induced...
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Exploring the diversity of mechanosensitive channels in bacterial genomes
Mechanosensitive ion channels are responsible for touch sensation and proprioception in higher level organisms such as humans and recovery after...
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The Role of Mechanosensitive Signaling Cascades in Repair and Fibrotic Remodeling of the Infarcted Heart
The adult mammalian heart has negligible regenerative capacity and heals through formation of a collagen-based scar. Repair of the infarcted heart...
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The functional effects of Piezo channels in mesenchymal stem cells
Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal,...
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Structure, kinetic properties and biological function of mechanosensitive Piezo channels
Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell...
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Annexin and Mechanosensitive Channel
We talk about two calcium (Ca2+) transport elements in this chapter. The annexins (ANN) and mechanosensitive channels (MSc) each represent a unique...
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Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type Ca2+current
BackgroundThe study aimed to identify transcripts of specific ion channels in rat ventricular cardiomyocytes and determine their potential role in...
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Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells
BackgroundPhysical exercise directly stretching the peripheral nerve promotes nerve regeneration; however, its action mechanism remains elusive. Our...
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Ion Channels in Electrical Signaling in Higher Plants
AbstractElectrical signals (ESs) appearing in plants under the action of various external factors play an important role in adaptation to changing...
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Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
BackgroundMechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43...
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Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
The general mechanism of bacterial mechanosensitive channels (MS) has been characterized by extensive studies on a small conductance channel MscS...
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Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction
Glaucoma is one of the leading causes of irreversible blindness in developed countries, and intraocular pressure (IOP) is primary and only treatable...
