Mechanical forces are ubiquitously present in biology. In recent years, it has become clear how plasma membranes detect these forces — but how do intracellular organelles such as lysosomes do the same, and what might be the functions of such intracellular mechanosensing? Answers may come through a report of a lysosomal mechanosensitive ion channel, TMEM63.
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Riederer, E., Ren, D. Lysosomal channels sensing forces. Nat Cell Biol 26, 318–320 (2024). https://doi.org/10.1038/s41556-024-01347-5
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DOI: https://doi.org/10.1038/s41556-024-01347-5
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